Wounds/fungal infection

Question 1

Wounds and their effect on metabolism

Answer 1

increases metabolism

as the body heals, it diverts carbs, fats, proteins to the creation of new tissue (speeds metabolism)

If this happens for a long time, negative feedback begins and the body sends extra protein to the wound instead of the organs that need it (slows wound healing and decreases muscle mass)

Question 2

Nutrition for wound healing

Answer 2

high fluid (replaces fluid loss)

Protein (correct nitrogen balance)

Carbohydrates (increases metabolic rate)

Question 3

Largest and most versatile group of antifungals…

Answer 3

Azoles (similar to Amphotericin B, but less toxic)

Question 4

Antifungal drug mechanisms

Answer 4

Inhibition of nucleic acid synthesis
Disruption of membrane integrity
Disruption of microtubule formation
Inhibition of β-glucan synthesis; β-glucans are polysaccharides in fungus cell walls
Inhibition of ergosterol synthesis; ergosterol is similar to cholesterol in animal cells

Question 5

Azole mechanism of action

Answer 5

Blinds to ergosterol in fungal cell membranes causing cells to become more permeable

Question 6

Antifungal most commonly prescribed for oral yeast infections

Answer 6

Nyaderm

Question 7

Nyaderm mechanism of action

Answer 7

binds to ergosterol in the fungal cell membrane, creating pores in membrane to allow intracellular components to leak out of cell

Question 8

Why are protozoa hard to treat once infected

Answer 8

go through 2 stages

Trophozoite (active growing stage where the organism feeds)
Cyst (protective capsule where organism remains dormant for long time)

Question 9

Medication used to treat both bacterial and parasitic infections

Answer 9

Metronidazole (flagyl)