Inflammation/Fever/Allergies

Question 1

Nonsteroidal anti-inflammatory drugs

Answer 1

primary drugs for the tx of mild-moderate inflammation

block inflammation by inhibiting cyclooxygenase (promotes inflammation)

Question 2

DO NOT GIVE NSAID when…

Answer 2

eGFR < 60

reflects kidney function

Question 3

NSAIDs

Prototype: Ibuprofen

Mechanism of action

Answer 3

to inhibit prostaglandin synthesis

Question 4

NSAIDs

Prototype: Ibuprofen

Primary use

Answer 4

for musculoskeletal disorders (rheumatoid arthritis, osteoarthritis, mild-mod pain, reduction of fever, dysmenorrhea

Question 5

NSAIDS

Prototype: Ibuprofen

Adverse effects

Answer 5

nausea (eat with food), heart rumor, GI bleeding, stroke

Question 6

NSAIDS

Answer 6

inhibit prostaglandin (vasodilator, hypotensive) release, inhibits clotting

high risk of bleeding

Question 7

NSAID management

Answer 7

• obtain baseline kidney and liver function test (low eGFR and high creatinine) and CBC (complete blood count)
• monitor bleeding time with long-term administration
• assess for changes in pain, reduction in temp and inflammation
• assess for GI bleeding
• use cautiously in elderly pts

Question 8

Systemic Glucocorticoids

Answer 8

• are anti-inflammatory drugs that can suppress severe cases of inflammation
• suppress histamine release
• inhibit the synthesis of prostaglandins by cox-2
• suppress certain functions of phagocytes and lymphocytes