Anxiety Flashcards
Non-pharmacological tx of anxiety
Counselling Exercise Pet therapy Music therapy Journaling Spiritual practices aroma therapy
CNS depressant types
Benzodiazepines
Barbiturates
Zopiclone
Buspirone
CNS depressants effects
Anxiolytic
Sedative
Hypnotic
Benzodiazepines
for generalized anxiety disorder and short term insomnia therapy
Binds GABA receptor which causes its Cl-channel to open, decreasing excitability of post-synaptic neurons in limbic system - calming effect
Benzodiapines - Adverse effect
Drowsiness sedation disorientation ataxia blurred vision reduced REM sleep stages
Benzodiapines are agonized by
flumanzenil
Benzodiazepine example
Lorazepam
Barbiturates
Used less commonly
Anti-seizure, IV anesthetic
Mechanism of action same as benzodiazepines
Barbiturates - Risks
High rate of dependency
Withdrawal is severe
Risk of seizure when taken off
Barbiturates - Adverse effects
Resp depression
paradoxical excitement
Cross-tolerance
tolerance to barbiturates can promote tolerance to opioids and other CNS depressants
Zopiclone
Non-benzodiazepine CNS depressant
Sedative - hypnotic
Short term treatment of insomnia
Binds GABA-A receptors, causing channels to open, leading to decreased excitability of post-synaptic neurons
Zopiclone example
Imovane
Zopiclone adverse effects
Gi - N/V, diarrhea Sleep - daytime drowsiness, sleep eating, sleep walking Confusion, amnesia Ataxia Blurred vision
What is the danger of administering a medication such as Imovane to an elderly person?
Increased susceptibility to major side effects