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Pathophysiology > Wound Healing dysfunctions > Flashcards

Wound Healing dysfunctions Flashcards

1
Q

What are the 4 steps to inflammatory regeneration?

A
  1. Resolution
  2. Repair
  3. Debridement
  4. Healing
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2
Q

What are these inflammatory regenerations:

  • Resolution
  • Repair
A

Resolution= Tissue returns to normal structure/function

Repair= Scar tissue replaces destroyed tissue

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3
Q

What are these inflammatory regenerations:

Debridement

Healing

A

Debridement= Cleaning up clots, dead cells, debris

Healing= Shrinking and sealing the wound

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4
Q

What are these two types of wound healing:

  • Primary Intention
  • Secondary Intention
A

Primary intention: Minimal tissue loss (surgical incisions)

Secondary intention= Wounds with lots of tissue replacesment (open wounds)

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5
Q

What are the three phases of wound healing?

A
  1. Inflammation phase
  2. Proliferative phase
  3. Maturation phase
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6
Q

What occurs during the inflammation phase of wound healing?

A
  • Coagulation
  • Entrance of wound healing cells
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7
Q

What are these occurences of the proliferative phase:

  • New blood vessels form
  • New tissue forms (looks beefy)
A
  • Angiogenesis
  • Granulation
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8
Q

During the proliferative phase, tissue grows from outside the wound inward. What is this called?

A

Epithelialization

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9
Q

What occurs during the remodeling/maturation phase of wound healing?

A

Cells differentiate and scars form

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10
Q

How can these factors cause dysfunctional wound healing during inflammatory response:

  • Large clots
  • Fibrins
A

Clots= Granulation can’t grow through clots, bacteria grow well on them

Fibrin must be reabsorbed or it can bind organs together

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11
Q

How can vasoconstriction impair wound healing during the inflammatory response?

A

Prevents nutrients from reaching site (glucose, proteins)

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12
Q

What is one of the most important minerals needed for collagen synthesis?

A

Zinc

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13
Q

What are the dysfunctions that can occur during the reconstructive phase of wound healing?

A
  1. Impaired collagen matrix
  2. Impaired epitheliazation
  3. Dehiscense of wound
  4. Impaired contraction (contracture)
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14
Q

What two things can impaire collagen matrix assembly result in?

A
  1. Keloid scar
    1. Scar extends beyond wound
  2. Hypertrophic scar
    1. Raised scar, stay within wound
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15
Q

What can cause impaired epithelialization during wound healing?

A

Anti-inflammatory drugs

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16
Q

What is dehiscence?

A

Wound edges come apart.

17
Q

Why does wound healing take longer in older adults?

A

Skin loses collagen; makes healing process longer

Pathophysiology (16 decks)

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