Wound healing

Question 1

What are labile cells?

Answer 1

Normally continuous turnover, go into cell cycle automatically

Question 2

What are stable cells?

Answer 2

Normally little proliferation, but capable

Question 3

What are permanent cells?

Answer 3

Not capable of regeneration, heal by scarring

Question 4

What are the features of the inflammation phase of wound healing?

Answer 4

1. Clot formation 2. Chemotaxis 3. Occurs in the first week

Question 5

What are the features of the proliferation phase of wound healing?

Answer 5

1. Re-epithelialization 2. Angiogenesis and granulation tissue 3. Provisional matrix 4. Occurs around the second week

Question 6

What are the features of the maturation phase of wound healing?

Answer 6

1. Collagen deposition 2. Wound contraction 3. Occurs around the third week

Question 7

What is the major regulatory molecule of angiogenesis?

Answer 7

VEGF

Question 8

What cell makes VEGF?

Answer 8

Macrophage

Question 9

What is the major stimulatory molecule of fibrogenesis?

Answer 9

TGF beta

Question 10

What cell makes TGF beta?

Answer 10

Macrophage

Question 11

What are the features of early granulation tissue?

Answer 11

Numerous macrophages, myofibroblasts, blood vessels

Question 12

What are the features of late granulation tissue?

Answer 12

Less vascular, only scattered macrophages with more matrix and fibroblasts

Question 13

What is the process of granulation tissue maturation?

Answer 13

Cicatrization

Question 14

What is cicatrization?

Answer 14

Granulation tissue maturation - collagen deposition, contraction, devascularization

Question 15

Wound contraction is a result of the action of which cells?

Answer 15

Myofibroblasts

Question 16

In proud flesh, what is the relationship between the granulation tissue and the epidermis?

Answer 16

Granulation tissue rises above the epidermis