Chronic inflammation I Flashcards
1
Q
Which cell type is responsible for most of the tissue injury in chronic inflammation?
A
Macrophages
2
Q
What are some macrophage activation signals?
A
Cytokines from T cells (Th1) and NK cells, endotoxin, other chemical mediators
3
Q
Large, multinucleated giant cells can be produced through fusion of macrophages caused by what cytokines?
A
IL-4 and IFNy
4
Q
Recruitment of eosinophils depends on what chemokine?
A
Eotaxin
5
Q
Eosinophil granules contain what protein?
A
Major basic protein
6
Q
What are the features of major basic protein?
A
Highly cationic, toxic to parasites, causes epithelial cell lysis
7
Q
Mast cells release which cytokines?
A
Histamine, PG, TNF
8
Q
Mast cell activation leads to what changes in the vasculature?
A
Increased permeability and vasoconstriction
