Wound Healing Flashcards
Wound Healing
restoration of tissue architecture and function after an injury
Healing
regeneration - so restoration of both anatomy and physiology
Repair
anatomy doesn’t get repaired, instead you have a functional compromise
Labile cells
normally continous turnover - have stem cells
stable cells
normally have little proliferation, but have the capability, have stem cells
permanent cells
no stem cells. heal by scarring
2 processes of regeneration
proliferation of surviving cells to replace lost tissue
migration of surviving cells into the vacant space
examples of stable cells
liver, kidney
examples of permanent cells
brain, heart, skeletal muscle
examples of labile cells
bone marrow, epidermis, GI and bronchial epithelium
When do you get partial regeneration and scaring
have a tissue capable of regeneration and extensive injury
What are the 3 phases of wound healing
- inflammation
- proliferation
- maturation
when does inflammation normally take place
1st week
what happens in inflammation
clot formation
chemotaxis
when does proliferation happen
2nd week
What happens in proliferation
re-epitheliazation
angiogenesis and granulation tissue
provisional matrix
when does matruation happen
3rd week
what happens in maturation
collagen matrix
wound contraction
What is angiogensis
capillary budding
endothelial cell proliferation
what is the major regulatory molecule of angiogensis
VEGF
what is fibrogenesis
fibroblast activation and proliferation, collagen deposition
what is the major stimulatory molecule of fibrogenesis
TGF-beta
what is the director of wound healing
macrophage
when does granulation tissue show up
proliferation
what does granulation tissue look like grossly
pink, soft, granular, seen beneath the scab of a skin wound
what does granulation tissue look like histology
fibroblasts surrounded by abundant ECM, newly formed blood vessels and scattered macrophages and some other inflammatory cells
what does early granulation tissue look like
numerous macrophages, myofibroblasts and blood vessels
what does late granulation tissue look like
less vascular, only scattered macrophages with more matrix and fibroblasts
Granulation is a ___ structure
temporary
what can contraction lead to
considerable deformity and functional impairment
the more granulation the ____ contraction and ____ risk of organ impairment
more
greater
