Acute Inflammation III

Question 1

CXC (alpha-chemokines)

Answer 1

act primarily on neutrophils

ex) IL-8

Question 2

CC (beta chemokiens)

Answer 2

attract other cells but NOT neutrophils

ex_ MCP-1

Question 3

C (gamma chemokines)

Answer 3

specific for lymphcytes

ex) lymphotactin

Question 4

CX3C chemokines

Answer 4

fractaline is strong attractant for monocytes and T cell

Question 5

What is NO prudced by

Answer 5

macrophages, endothelium, some neurons in brain

Question 6

Function of NO

Answer 6

vasodilation through smooth muscle cell relation
reduces platelet aggregation and adhesion
WBC recruitment

Question 7

What does ROS from neutrophils and macrophages cause

Answer 7

endothelial cell damage
inactivation of antiproteases
injury to other cells

Question 8

what endothelial cell damage do ROSs causes

Answer 8

increased vascular premability

Question 9

Antioxidants

Answer 9

protect from free readicals

Question 10

What are some examples of antioxidants

Answer 10

ceruloplasmin, transferrin, superoxide dismutase, catalase

Question 11

Substance P and Neurkoinin A belon gto what family

Answer 11

family of tachykinin neuropepetides produces in the CNS and PNS

Question 12

Functions of substance P

Answer 12

transmission of pain signals
regulation of bp
increased vascular permeability

Question 13

mediators of vasodilation

Answer 13

PG, NO

Question 14

mediators of vascular permeability

Answer 14

vasoactive amines, C3a, C5a, bradykinin, leukotrines, substance P

Question 15

mediators of chemotaxis and leukocyte activation

Answer 15

C5a, leukotrine B4, chemokines

Question 16

mediators of fever

Answer 16

IL1, IL6, TNF, PG

Question 17

mediators of pain

Answer 17

PG< bradykinin

Question 18

mediators of tissue damage

Answer 18

lysosomal enzymes, oxygen metabolities, NO