Acute inflammation I

Question 1

inflammation

Answer 1

local reaction of vascularized tissue to injury

Question 2

timeframe of Acute inflammation

Answer 2

0-2 days

Question 3

time frame of subacute inflammation

Answer 3

2-14 days

Question 4

time frame of chronic inflammation

Answer 4

> 14 days

Question 5

Cells found in acute inflammation

Answer 5

neutrophils

Question 6

Cells found in subacute inflammation

Answer 6

neutrophils, monocytes, lymphocytes, plasma cells, fibrobalstic elements, angioblastic elements

Question 7

cells found in chronic inflammation

Answer 7

monocytes, lymphocytes, plasma cells, macrophages, granuloma cells

Question 8

eosinophils

Answer 8

predominate inflammatory cells in allergic reactions and parasitic infestations

Question 9

What are the 6 cardinal signs of inflammation

Answer 9

heat, redness, swelling, pain, loss of function, swstemic changes

Question 10

serous

Answer 10

outpouring of watery, relatively protein-poor fluid, derives from either serum or mesothelial cell secretions

Question 11

examples of serous inflammation

Answer 11

skin blister from burn

Question 12

fibrious inflammation

Answer 12

seen in more severe injury, incrased vascular permeability allows leakage of larger molecules, extravascular fibrin accumulates

Question 13

suppurative (purulent) inflammation

Answer 13

manifested by large amounts of pus

Question 14

Abscesses

Answer 14

focal collections of pus, central necrotic region surrounded by layer of preserved neutrophils

Question 15

ulceration

Answer 15

local defect, excavation produced by sloughing of inflammatory necrotic tissue, can only occur on or near a surface

Question 16

What are potential outcomes of acute inflammation

Answer 16

resolution
scarring
abscess
progress to chronic inflammation

Question 17

Alterations in vascular calbier in acute inflammation leads to

Answer 17

increased blood flow

Question 18

Structural changes in microvasculature in acute inflammation enables what

Answer 18

plasma proteins and leukocytes to leave the circulatoin

Question 19

In acute inflammation there is emigratino of ____ from microcirculation

Answer 19

leukocytes

Question 20

Cell adhesion molecules

Answer 20

membrane proteins that promote leukocyte attachement and paritcipation in the inflammatory response

Question 21

What are the selectins

Answer 21

P, E, L

Question 22

ICAM-1

Answer 22

assists in localization of leukocytes to tissue injury

Question 23

Where is ICAM-1 expressed

Answer 23

on surface of cytokines stimulated endothelium

Question 24

What does ICAM-1 bind to

Answer 24

integrins LFA-1 and MCa-1 present on cell membranes of neutrophils and macrophages

Question 25

VCAM-1

Answer 25

binds to integrin VLA-4 molecule on lymphocytes, monocytes, eosinophils, basophils

Question 26

PECAM-1

Answer 26

CD-31, bind in a homophilic manner | plays an important role in the diapedesis step of leukocyte emigration

Question 27

integrin family

Answer 27

group of adhesion molecules composed of heterodimers of alpha and beta subunits which act in regulation of cell-matrix and cell-cell adhesion

Question 28

VLA-4

Answer 28

expressed only on leukocytes, binds to VCAM-1 on endothelium

Question 29

Beta2 integrins

Answer 29

CD11-CD18 molecules or leukocytes function associated antigens of LFA

Question 30

What do LFA-1 and complement receptor type 3 and 4 do

Answer 30

bind to ICAM-1 and assist in localization of phagocytes to injury sites and subsequent extravasation