WHO CLASSIFICATION OF ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)

Question 1

✔ about 75% of cases occur in children younger than 6 years old
✔ About 85% of ALL are this type

a.I. PRECURSOR T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
b. PRECURSOR B-CELL ACUTE LYMPHOBLASTIC LEUKEMI

Answer 1

b. PRECURSOR B-CELL ACUTE LYMPHOBLASTIC LEUKEMI

Question 2

✔ accounts for about 15% of childhood ALL
✔ about 25% of adult ALL

a. PRECURSOR T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
b. PRECURSOR B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA

Answer 2

a. PRECURSOR T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA

Question 3

✔ (+): enlarged lymph nodes, liver, spleen
✔ Leukocyte count: variable

a. PRECURSOR B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
b. PRECURSOR T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA

Answer 3

a.PRECURSOR B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA

Question 4

**✔ leukocyte count is often markedly elevated

✔ lymphoblasts are similar to those in precursor B-cell ALL with a wide variation in morphology

a. PRECURSOR B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
b. PRECURSOR T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA

Answer 4

b. PRECURSOR T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA

Question 5

✔ Lymphoblasts are pleomorphic and vary from small to large with nuclei having prominent or
inconspicuous nucleoli, compact or dispersed chromatn

✔ The blue or blue-gray cytoplasm is usually scant (but may be abundant)

a. PRECURSOR B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
b. I. PRECURSOR T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA

Answer 5

a. PRECURSOR B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA

Question 6

✔ neoplasm of lymphoblasts committed to the B-cell lineage

a. I. PRECURSOR B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
b. PRECURSOR T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA

Answer 6

a. I. PRECURSOR B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA