White Blood Cells Flashcards
What shape are WBCs in circulation?
Spherical
When do WBCs become active?
Once they enter tissue
Which WBCs are granulocytes?
Eosinophils, basophils, neutrophils
Which WBCs are mononuclear (agranulocytic)?
Monocytes, lymphocytes
What is the most abundant WBC in the dog, cat, and horse?
Neutrophil
What is the most abundant WBC in the bovine, sheep, pig, and chicken?
Lymphocyte
Where do WBCs (Except lymphocytes) mature and what is needed for their maturation?
In the bone marrow, need cytokines
Where do lymphocytes mature?
In the lymphatic system, after they are generated in the bone marrow and transported to the lymphatic system
At which stage of granulopoiesis is a cell committed to a specific WBC?
Myelocyte
How long is a neutrophil in the bone marrow, the blood, and the target tissue?
6 days in bone marrow, 7-14 days in blood, 4 days in target tissue
What is the name given to the method of entry of neutrophils into the target tissue via squeezing between endothelial cells?
Diapedesis
Name three important features of neutrophils.
They are the first responders to invading organisms, they release chemoattractants for other WBCs, and they increase the permeability of vessel walls
How long is an eosinophil in the bone marrow, the blood, and the target tissue?
2-6 days in bone marrow, 1-24 hours in blood, 2-14 days in target tissue
Name three functions of eosinophils.
Phagocytose antigen-antibody complexes, deactivate histamines and prevent histamine/serotonin release, and fight parasitic infections (Such as helminths) by bursting on the parasite
What do basophils contain and what do the contents do?
Contain histamine, heparin, serotonin, and they cause vasodilation and anticoagulation
