When to use what antifungal

Question 1

Aspergillois

Answer 1

1st line: VORICONAZOLE IV
step down: Voriconazole PO

2nd line: lipid amphotericin B IV
step down: posaconazole PO

Question 2

Sporotrichosis

Answer 2

AMPHOTERICIN B IV and/or ITRACONAZOLE PO

Backup: itraconazole PO

Question 3

Candidiasis

Answer 3

Amphotericin B IV and FLUCONAZOLE PO

Question 4

Mucormycosis

Answer 4

AMPHOTERICIN B

Backup: poscaonazole

Question 5

Blastomycosis (mild and severe)

Answer 5

1st line: Fluconazole IV or amphotericin B IV if severe
step down: voriconazole, itraconazole or fluconazole

2nd Amphotericin B IV
step down: voriconazole or fluconazole PO

Question 6

Histoplasmosis

Answer 6

Severe: AMPHOTERCIN B IV + ITRACONASOLE PO

mild-moderate: Voriconazole or Posaconazole, Fluconazole PO

Question 7

Cryptococcus

Answer 7

CNS: AMPHOTERICIN B IV + FLUCYTOSINE PO***

Non-CNS: FLUCONAZOLE PO

Question 8

Coccidiomycosis

Answer 8

Severe or immunocompromised: Amphotericin B IV followed by itraconazole or fluconazole PO

Mild-Moderate: Voriconazole or posaconazole PO