Alkylating Agents (Adverse Effects)

Question 1

Cylcophosphamide (Unusual Toxicity)
• agent to counter it?

Answer 1

• Lung Fibrosis
• renal/urotoxic (Hemmorrhagic Cystitis)
• Congenital Heart Failure
  • MESNA is renoprotective from acrolein

Question 2

Procarbazine (Unusual Toxicity)

Answer 2

• Disulfram-like effect
• weak MAO inhibition

Question 3

Carmustin (BCNU) (Unusual Toxicity)

Answer 3

Hepatic “veno-occlusive”

Question 4

Carboplatin (Unusual Toxicity)
• Protective agents?

Answer 4

• Thrombocytopenia
• Peripheral Neuropathy
• less renal toxicity than Cisplatin Amifostine is Nephroprotective

Question 5

Lomustine (CCNU) (Unusual Toxicity)

Answer 5

CNS
- siezures, Dementia

Question 6

Mehphalan (Unusual Toxicity)

Answer 6

Lung fibrosis

Question 7

Cisplatin (Unusual Toxicity)
• Protective agents

Answer 7

• Renal Toxicity
• Ototoxicity
• Peripheral Neuropathy Amifostine in Nephroprotective

Question 8

Busulfan (Unusual Toxicity)

Answer 8

• Lung Fibrosis
• Addison-like syndrome- Hepatic “veno-occlusive’

Question 9

Ifosfamide (Unusual Toxicity)
• Protective agents?

Answer 9

• CNS toxicity
• Renal/ Urotoxic (Hemorrhagic Cystitis via acrolein)

MESNA counters the effects of acrolein