Asthma Drugs (with Muthiah key pts)

Question 1

**what is the major side effect of albuterol?

Answer 1

Tremor

Question 2

**What drug is a good alternative if albuterol is causing tachycardia in your patients on a regular basis?

Answer 2

Levoalbuterol - remember his the R-isomer

Question 3

**What is the consequence of local contact of Atrovan in the eyes?
• what other drug has the same effect as local atrovan it it is given systemically?

Answer 3

Pupillary Dilitation and Increased intraocular pressure

Atropine if given systemically causes the same symptoms

Question 4

**What is the main side effect of inhaled apotropium?

Answer 4

Dryness of the mouth

Question 5

**Someone develops candidiasis (thrush) infection while taking an inhaled asthma medication. What medication is this?

Answer 5

Inhaled coriticosteroids inhibit the local immune response in the mouth allowing fungi to take over.

Question 6

**Is it true that inhaled coriticosteroids causes growth retardation in children?

Answer 6

TRUE, but relief of asthma allows them to catch up on growth after they become adults

Question 7

**What is the main weird side effect to know about Tiotropium?

Answer 7

Can cause urinary retention (its an anti M3 that are needed to contract the detrussor in order to pee)

Question 8

**What is the MOA of theophylline?

• when is it used?

Answer 8

Theopylline - NON-specific phosphodiesterase inhibitor - increases cAMP levels leading to smooth muscle relaxation

Question 9

**What conditions need to be met to use Omalizumab?

• what risks are associated with administration?

Answer 9

Conditions - Hypereosinophilia and IgE levels

Risks:
• mAb can cause severe anaphylaxis so keep the patient for an hour or so after administering to monitor these reactions

Question 10

**What is the mechanism of action for Mepolizumab?

Answer 10

MOA = anti-IL-5 mAb

Question 11

Name 2 ß2-specific short acting and rapid onset bronchodilators.

Answer 11

Albuterol and Terbutaline

Question 12

Name two ß2-specific slow onset and long acting bronchodilators.

Answer 12

Salmeterol and Formoterol (used with steroids)

Question 13

What 4 cholinergic antagonists are used as bronchodilators?

Answer 13

• Atropine
• Ipatropium
• Tiotropium
• Umeclidinium

Question 14

Name 2 methylxanthines act as bronchodilators?

Answer 14

• Theophylline

* Aminophylline

Question 15

What is a cromolyn-antiinflammatory?

Answer 15

• Cromolyn Sodium

Question 16

What are the two leukotriene receptor blockers?

Answer 16

• Monteleukast

* Zarfirlukast

Question 17

What is the only leukotriene synthesis inhibitor?

Answer 17

• Zileuton

Question 18

What anti-IgE drug is given to asthmatics?

Answer 18

• Omalizumab

Question 19

What IL-5 antibodies are given to asthmatics?

Answer 19

• Mepolizumab

Question 20

What Prostaglandin is a potent bronchoconstrictor is released from mast cells?

Answer 20

PGD2

Question 21

NOTE: Mallik says that glucocorticoid action on phospholipase A2 to prevent the production of arachidonic acid isn’t that significant.

Answer 21

NOTE: Mallik says that glucocorticoid action on phospholipase A2 to prevent the production of arachidonic acid isn’t that significant.

Question 22

What leukotriene serves as a potent chemoattractant?

Answer 22

LTB4 = potent Chemotractant