Notes From Sweatman Review

Question 1

What part or the airway is most responsive to Anti-muscarinics?
• why are anti-muscarinics mostly used for COPD pts?

Answer 1

• Larger airways are more responsive to muscarinics
• Anti-muscarinics are typically used in therapy for people with COPD because these patients are typically older and therefore have higher vagal tone.

Question 2

Why is salmeterol longer acting than albuterol?

Answer 2

• Its more lipophilic

Question 3

Will a patients PFTs improve on theophylline?

Answer 3

NO - the reason we give this drug is just to make patients feel better

Question 4

What mutation is an automatic contraindication for the EGFR drugs?

Answer 4

• KRAS - its a downstream mutation

Question 5

Why do TKI’s have such broad side effects?

Answer 5

The ATP binding site of TKI’s is highly conserved

Question 6

What do you use as an emergency bronchodilator in people with COPD?

Answer 6

Ipotropium

Question 7

T or F: all antihistamines are functional as cough suppressants?

Answer 7

FALSE, only 1st generations are effective cough suppressants because they cross the BBB to have anti-cholinergic effects

Question 8

How do Verapamil and Dilatazim differ from the other CCBs?

Answer 8

They are the only one’s that work on the heart in addition to the periphery