Drugs that Reduce Chemotherapy Drug Toxicity

Question 1

Allopurinol, Rasburicase
- consequence

Answer 1

Given for:
- Tumor Lysis Syndrome

Consequence:

• Reduce Uric acid Level
• Renal protective

Question 2

Mesna
- consequence

Answer 2

Oncology Agent:
- Cyclophosphamide, Ifosfamide

Consequence:
- Protect against Acrolein Product

Question 3

Amifostine
- consequence

Answer 3

Oncology Agent:
- Cisplatin

Consequence: - Cytoprotection

Question 4

Leucovorin
- consequence 1 and 2

Answer 4

Oncology Agent:
a. MTX

b. 5-FU

Consequence:

a. Metabolic Rescue
b. Enhanced Action

Question 5

Allopurinol
- consequence

Answer 5

Oncology Agent:
- 6-MP (mercaptopurine)

Consequence:
- Increases Toxicity

Question 6

Dexroxazone
- consequence

Answer 6

Oncology Agent:
- Anthrcyclines (-rubicins, e.g. Doxorubicin)

Consequence:

• Fe Chelator
• Reduced Cardiotoxicity