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phase 3 (1) > Week 9 > Flashcards

Week 9 Flashcards

1
Q

2 autoantibodies in T1DM

A

insulinoma associated antigen 2

glutamic acid decarboxylase

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2
Q

6 mody features

A 
monogenic 
AD
HNF1
over 25
c peptide not low
ab negative
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3
Q

7 pancreatic diabetes

A 
monogenic 
AD
HNF1
over 25
ab negative 
low c peptide
ketones
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4
Q

what causes pancreatic diabetes

A

pancreatectomy
pancreatitis
CF
hemochromatosis

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5
Q

HBA1c target

A

less than 53

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6
Q

6 irregular insulin dosage causes

A 
CHO counting 
pregnant 
pump failure 
administration 
illness
injection sites
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7
Q

4 hypothyroid primary causes

A

hashimotos
post iodine
thyroidectomy
congential

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8
Q

what causes thyroid dysgeneiss

A

TSH receptor

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9
Q

what causes dyshormeogenesis

A

pendrin
pondered syndrome
thyroglobulin
SI s’emporter

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10
Q

treatment of hyperthyroidism

A

beta blocker
carbimazole
propthiouracil
131 idoine

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11
Q

graves treatment

A

alemtuzemab - CD 52

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12
Q

what is iodine induced hypo or hyper

A

jod baedow

wolf chairkoff

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13
Q

what is type 1 amidoarone thyroid disease

A

unmaking previous thyroid disease

give carbimazole

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14
Q

what is type 2 amiodarone thyroid disease

A

destructive thryoidisitis

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15
Q

what is medullary cancer

A

c cells

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16
Q

what is men 2 and 3

A

MTC, phaeo, primary hyperpaprathydoid

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17
Q

5 things for semen analysis

A 
- 1-3 days after last ejactulation 
2-5ml
20-106 sperm 
50% progressive 
over 30% morphology
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18
Q

4 main hypopituatirsm causes

A

head injury
kallmans
genetic
surgery

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19
Q

Kal 2

A

ad

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20
Q

KAL 3

A

ar

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21
Q

KAL 1

A

x linked

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22
Q

5 causes of primary gonadal failure

A 
kleinfilers 
cryporthidiam 
leydig cell failure
ST failure
adult leydig cell failure
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23
Q

4 symptoms of androgen treatment

A 
sweating 
increased hematocrit
prostate
acne
mood
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24
Q

5 primary causes of amenorrhea

A 
rokitansky
turners
kallmans
pituitary disease
low BMI - hypothalamic
25
Q

5 secondary causes of ammenoeha

A 
ashermnas 
PCOS
premature ovarian failure
prolactinoma
pituitary tumour
26
Q

2 causes of hirsutism

27
Q

4 symptoms of PCOS

A

annovualtion
hirsutism
acne
alopecia

28
Q

how to distinguish ovary from adrenal cause of hirusitm

29
Q

most common cause of secondary hypertension

A

primary hyperaldosteronism

30
Q

2 causes of primary hyperaldosteronism

A

adenoma or bilateral adrenal hyperplasia

31
Q

2 tests for primary hyperaldoseronism

A

saline suppression

aldosterone renin ratio

32
Q

treatment of primary hyperaldosteronism

A

spironolactone or surgery

33
Q

4 tests for cushions

A

24 hour urinary cortisol
cortisol creating ratio
dexamthasome suppression test
late night salivey cortisol

34
Q

symtoms in boys and girls of CAH

A

ambiguous genitalai in female

adrenal crisis and early virtualisation in males

35
Q

treatment of CAH

36
Q

why late onset CAH and test

A

increases ACTH drive

synachten test with 17 0hD

37
Q

bichem in adrenal insufficiency

A

increased na

dreacred K

38
Q

test for adrenal insufficiency

A

adrenal autoantibodies

renin; aldosterone

39
Q

whipples train

A

symptoms of hypo
low plasma glucose
relief after glucose

40
Q

hypoglycemia test

A

72 hour fast

41
Q

how to distinguish local insulin from diffuse nestiobastlsosi

A

arterial calcium stimulation

42
Q

MEN type 1

A

parathyroid
ant pituitary
eneteropancreatic endocrine cells

43
Q

cushings treatment

A

ketokonazole

44
Q

carcinoid syndrome

A 
release serotonin 
flushing 
dihorrea 
asthma 
right heart vaulvar lesions
45
Q

graves gives what to palms

A

palmar erythema

46
Q

how to test for carcinoid syndrome

47
Q

diffuse iodine uptake

A

multinodialr goitre

48
Q

irregular iodine uptake

A

multinodualr goitre

49
Q

reduced uptake

A

thyroiditis

50
Q

3 ketoacidosis symptpms

A

capillary ketone testing
urine ketone
serum bicarb

51
Q

hypoadrenalism treatment

A

hydrocortisone - glcocorticoid

fludrocortisone - mineral cooridoic

52
Q

2 physical exam signs in hypoadrenalism

A

hyperpigmentation

postural hypotension

53
Q

4 anthyroid drugs side effects

A 
rash
itch
fever
hair loss
nausea`
54
Q

DPP4 example

A

linagliptin

55
Q

GLP example

A

liraglitide

56
Q

sulphonylurea example

A

gliclazide

57
Q

SGLT 2 inhibitor example

A

emplaglobflozin

58
Q

thiazolodione example

A

pioglitazone

59
Q

read over side effects

phase 3 (1) (16 decks)

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