week 6/7 (3)

Question 1

how does HIV enter

Answer 1

via CD4 receptors on cells

Question 2

3 effects on t helper cells

Answer 2

direct viral killing
apoptosis of bystander
CD8 killing of infected CD4

Question 3

at what level of CD 4 is there a risk of oppertunistic infections

Answer 3

less than 200

Question 4

5 HIV clinical stages

Answer 4

1. primary infection
2. actue - CD 4 decreased and increased viral load
3. clinical latency - lymphadenopathy
4. constitutional cease
5. oppetunicisc

Question 5

how does HIV go into cells to relocate

Answer 5

comes into cells and binds to CD4
reverse transcibes itself
integrated into nucleus through integrate

Question 6

3 main HIV tests

Answer 6

p24/HIV antibody - 4 week window
confirmatory test - assay
point of care testing

Question 7

differentials of primary HIV

Answer 7

infectious mono
secondary pyshpillis
drug rash

Question 8

normal CD4

Answer 8

400-16000

Question 9

treatment of HIV

Answer 9

HAART
2 nucleoside reverse transcriptase inhibitors plus 1 other class

integrase, portase, non nucleoside reverse inhibits

Question 10

ART 4 short term and 4 long term

Answer 10

rash, renal, hypersinciitvy, hepatic

hepatic, lipid, bone, Renal

Question 11

2 HAART interactions

Answer 11

PPI / statins

Question 12

PEP

Answer 12

within 72 hours for 28 days

Question 13

PrEP

Answer 13

renal and bone

Question 14

severe sepsis

Answer 14

sepsis + organ + hypoperfusion + hypotension

Question 15

septic shock

Answer 15

sepsis with refractory hypotension

Question 16

one HIV main opportunistic infection

Answer 16

fungus in immunocompromised

Question 17

some aids defining illness

Answer 17

CMV, candidiasis, toxoplasmosis, cervical cancer, lymphoma

Question 18

5 clinical indications to HIV tests

Answer 18

unexplained diahorrea
weight loss
multiple shinges
oral thrush
sebhorreic dermatitis

Question 19

4 gram posiitve rods

Answer 19

c diff
bacillus
listeria
corneybacterium

Question 20

4 gram negative rods

Answer 20

ecoli
klebsiella
proteus 
serratia
pseudomonas

Question 21

2 alpha hemolytic

Answer 21

step pneumonia

strep viridian’s

Question 22

3 beta hemolytic

Answer 22

step pyroxenes
strep a galactic
enterococci