Week 8: Sulfonylureas and Megalitinides - Insulin Secretagogues

Question 1

Sulfonylureas - Glipizide (Glucotrol), glyburide (Diabeta), glimepiride (Amaryl) MOA

Answer 1

• stimulates an increase in secretion of insulin from beta cells
• reduce glucose release from the liver

Question 2

Sulfonylureas (Glucotrol, Diabeta, Amaryl) ADRs

Answer 2

• Hypoglycemia
• Weight gain
• Agranulocytosis (rare)

Question 3

Sulfonylureas Contraindications

Answer 3

• Type 1 DM

- Sulfa allergy

Question 4

Sulfonylureas (Glucotrol Diabeta, Amaryl) Pt education

Answer 4

• take with food - if you skip a meal, skip dose

Question 5

Megalitinides - Repaglinide (Prandin), nateglinide (Starlix) MOA “glinides”

Answer 5

• increase insulin release from beta cells by closing potassium channels and opening calcium channels

Question 6

Megalitinides ADRs

Answer 6

• hypoglycemia
• weight gain
• URIs

Question 7

Megalitinides (Prandin, Starlix) contraindications

Answer 7

• Type 1 DM

- Avoid in pregnancy, lactation, and pediatrics

Question 8

Megalitinides (prandin, starlix) patient education

Answer 8

• take with food; no more than 30 minutes before a meal - hold if not eating