Week 8: Alpha-Glucosidase Inhibitors (AGIs) and Selective Sodium Glucose Cotransporter 2 Inhibitors (SGLT2) - affect the flow of sugar in the body w/o affecting insulin Flashcards
1
Q
AGIs - Acarbose (Precose) MOA
A
- inhibits carbohydrate absorption in small intestine
(where sugar is, water goes)
Does not cause hypoglycemia - weight negative
2
Q
AGIs (Acarbose/Precose) ADRs
A
- severe GI distress
3
Q
AGIs contraindications
A
- bowel diseases (IBS, increased risk of bowel obstruction)
- bowel obstruction
4
Q
Acarbose (Precose) patient education
A
- take with 1st bite of meal
5
Q
SGLT-2s “-flozins” (Invokana, Jardiance, Farxiga) MOA
A
- inhibits SGLT2 enzyme in the kidney, blocking the reabsorption of glucose in the kidneys - increased secretion of sugar in the urine - works like a diuretic
Does not cause hypoglycemia - weight negative (H2O loss)
6
Q
SGLT-2s ADRs
A
- UTI
- genital fungal infections
- hypotension / dehydration
- hyperkalemia
- bladder CA
7
Q
SGLT2s “-flozins” contraindications
A
- severe renal impairment
8
Q
SGLT2s counseling points
A
- black box (potential) - BKA, bladder CA, Fournier gangrene