Week 8: Alpha-Glucosidase Inhibitors (AGIs) and Selective Sodium Glucose Cotransporter 2 Inhibitors (SGLT2) - affect the flow of sugar in the body w/o affecting insulin Flashcards

1
Q

AGIs - Acarbose (Precose) MOA

A
  • inhibits carbohydrate absorption in small intestine
    (where sugar is, water goes)
    Does not cause hypoglycemia - weight negative
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2
Q

AGIs (Acarbose/Precose) ADRs

A
  • severe GI distress
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3
Q

AGIs contraindications

A
  • bowel diseases (IBS, increased risk of bowel obstruction)

- bowel obstruction

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4
Q

Acarbose (Precose) patient education

A
  • take with 1st bite of meal
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5
Q

SGLT-2s “-flozins” (Invokana, Jardiance, Farxiga) MOA

A
  • inhibits SGLT2 enzyme in the kidney, blocking the reabsorption of glucose in the kidneys - increased secretion of sugar in the urine - works like a diuretic
    Does not cause hypoglycemia - weight negative (H2O loss)
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6
Q

SGLT-2s ADRs

A
  • UTI
  • genital fungal infections
  • hypotension / dehydration
  • hyperkalemia
  • bladder CA
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7
Q

SGLT2s “-flozins” contraindications

A
  • severe renal impairment
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8
Q

SGLT2s counseling points

A
  • black box (potential) - BKA, bladder CA, Fournier gangrene
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