Week 10: Fluoroquinolones Flashcards
1
Q
Fluoroquinolones MOA
A
Ciprofloxacin, Levofloxacin
- interferes with bacterial enzymes required for the synthesis of bacterial DNA - breakage of DNA strands
2
Q
Fluoroquinolones indications
A
Complicated infections
- pyelonephritis (1st line)
- complicated UTIs
- CAP (3rd line)
3
Q
Fluoroquinolones (Cipro, Levofloxacin) ADRs
A
- tendinitis
- tendon rupture (rare)
- C.diff
- QT prolongation
- photosensitivity
4
Q
Fluoroquinolones cautions/CIs
A
- BBW: risk of tendon rupture and tendonitis
- risk of QT prolongation
- no for children < 18 (unless pyelonephritis, anthrax, allergies to other meds)
- not for use in pregnancy and lactation
