Week 8: Dipeptidyl Peptidase-4 inhibitors and Glucagon-Like Peptide 1 Receptor Agonists - Increase the effects of GLP-1 Flashcards

1
Q

Dipeptidyl Peptidase-4 Inhibitors (DPP-4) “-gliptins” MOA

A
  • Inhibit the DPP-4 enzyme, which prolongs the GLP-1 hormone levels - GLP-1 increases insulin secretion and suppresses glucagon secretion
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2
Q

DPP-4 “gliptins” ADRs

A
  • pancreatitis (if have abdominal pain = REPORT!)
  • arthralgia
  • hypoglycemia (when combined with insulin)
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3
Q

DPP-4s Contraindications

A
  • hx of pancreatitis
  • renal dxfunction
  • well tolerated in elderly (linagliptin)
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4
Q

DPP4s counseling points

A
  • effective only with food
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5
Q

Glucagon-Like Peptide 1 Receptor Agonists (GLP-1RA) MOA

A

injectable medication - synthetic GLP-1 - mimics natural incretins which increase insulin secretion (only when the pt eats), decreases glucagon secretion, and slows gastric emptying
- promotes satiety and wt loss

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6
Q

GLP-1RA (Byetta, Trulicity, Victoza) ADRs

A
  • pancreatitis
  • black box warning: thyroid tumors
  • GI issues (N/V/D)
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7
Q

GLP-1RA contraindications

A
  • Black box warning: medullary thyroid CA
  • acute pancreatitis
  • avoid with gastroparesis
  • avoid in pts with severe GI disease (colitis, Crohn’s)
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8
Q

GLP-1RA patient education

A
  • Only effective with food

- Administer 60 minutes before meals

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