Week 11: Progesterone

Question 1

Progesterone’s role & examples

Answer 1

• “anti-androgen” effect
• thicken’s & stabilizes endometrium
• thickens cervical mucus
• thins vaginal mucosa
• relaxes smooth muscle of uterus

in contraception: suppress ovulation (shuts off LH), thicken mucus

ex) implant (Nexplanon)
Levonorgestrel-releasing intrauterine device (IUD)(Mirena, Skyla) Depot medroxyprogesterone (DMPA) injection (Depo-Provera)

Question 2

Progesterone SE’s

Answer 2

Irregular breakthrough bleeding
Breast tenderness
Galactorrhea
Nausea

Question 3

progesterone contraindications

Answer 3

• sus preg
• sus breast cancer
• undx uterine bleeding
• liver tumor, cirrhosis, liver dz

Question 4

Drug interactions with combined OC’s

Answer 4

NO anticonvulsants

- rifampin reduces serum EE and progestin levels

Question 5

Progesterone in menopause

Answer 5

NEED a uterus to go on this! (same with estrogen)

Question 6

Micronized Progesterone vs Medroxyprogestrone acetate (MPA)

Answer 6

-Micronized 1st line over MPA for protecting endometrium w/ min effects on lipids, BC, and CAD

Question 7

Progesterone in menopause

Answer 7

IUD not approved for endometrial protection for menopause but used off label who can’t tolerate oral progestin

Question 8

Mifepristone (Mifeprex, Korlym) indication

Answer 8

progesterone antagonist

-termination of intrauterine pregnancy, Cushing syndrome