Week 8 // Cardiovascular System Flashcards by chris-anne d

What is blood? Breakdown of portions?

Blood is a liquid connective tissue consisting of cells surrounded by a liquid matrix (plasma)

Blood plasma 55%
Formed elements 45%
(Red, White, Platelets… mostly RBC. WBC about 1% and platelets less than 1%)

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What are the cellular components (formed elements ) of blood?

The cellular components (formed elements) of blood include red blood cells, white blood cells, and platelets

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What is the plasma portion made of?

The plasma portion of blood consists of water, proteins, and other solutes

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Blood accounts for ____% of body weight

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Majority of blood is made of

water (91.5% of plasma portion) and red blood cells

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Blood plasma is mostly

water (91.5%)

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White blood cells are called

neutrophils, eosinophils, lymphocytes, monocytes, basophils

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Functions of blood *

Blood transports oxygen, carbon dioxide, nutrients, hormones, heat, and waste products

Blood regulates homeostasis of all body fluids, pH, body temperature, and water content of cells

Blood protects against excessive loss by clotting, and uses white blood cells to protect against infections

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Blood plasma proteins mostly produced by the

Liver

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What makes the blood viscose / sticky?

Blood plasma proteins A plasma protein “fibrinogen” contributes to clotting

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How long do blood cells live?

Lymphocytes are able to live for years while most other blood cells live for hours, days, or weeks

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Red blood cells live

~ 120 days

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The number of red blood cells and platelets remains rather steady while that of white blood cells varies depending on

invading pathogens and other foreign antigens

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The process of producing blood cells is called

hemopoiesis (hematopoiesis)

Pluripotent stem cells differentiate into each of the different types of blood cells

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Red blood cells contain the protein

Red blood cells contain the protein hemoglobin

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Red blood cells also called

erythrocytes

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how does blood carry oxygen?

Red blood cells (erythrocytes) contain the protein hemoglobin that is used to carry oxygen to all cells and to carry some carbon dioxide to the lungs

Each hemoglobin molecule contains an iron ion which allows each molecule to bind four oxygen molecules
Red blood cells have no nucleus or other organelles and are biconcave discs

This allows them to carry oxygen more efficiently

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Dead blood cells are removed from circulation this way

Dead cells are removed from the circulation by the spleen and liver
Breakdown products from the red blood cells are recycled and reused

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The production of red blood cells begins here

Erythropoiesis (production of red blood cells) begins in the red bone marrow

Kidney and red blood cells connection

Erythropoietin, a hormone released by the kidneys in response to hypoxia (lowered oxygen concentration) stimulates differentiation of hematopoietic stem cells into erythrocytes

Reticulocytes (immature red blood cells) enter the circulation and mature in 1 to 2 days

Do red blood cells contain nucleus and organelles?

No. It contains hemoglobin.

Do white blood cells contain nucleus and organelles?

White blood cells (leukocytes) contain a nucleus and organelles, but no hemoglobin

Granular vs Agranular *

Leukocytes are classified as:
Granular (containing vesicles that appear when the cells are stained)
Granular leukocytes: neutrophils, eosinophils, basophils

Agranular (containing no granules)
Agranular leukocytes: lymphocytes, monocytes

Which leukocyte can appear to be both granular and agranular?

leukocytes

How long do white blood cells live for?

White blood cells may live for several months or years;

main fx of white blood cells?

their main function is to combat invading microbes During an invasion, many white blood cells are able to leave the bloodstream and collect at sites of invasion The process is called emigration (diapedesis)

what does a high white blood cell count usually indicate?

infection or inflammation

significance of white blood cells counts | neutrophils

neutrophils: HIGH bacteria, stress, burns, inflammation LOW radiation exposure, drug toxicity, low B12, systemic lupus

significance of white blood cells counts | eosinophils

HIGH: allergic reaction, parasitic infections, autoimmune disease LOW: drug toxicity, stress, acute allergic reactions

lymphocytes

HIGH: Viral infection, some leukemias, mono LOW: prolonged illness, HIV, immunosuppression treatment w/ cortisol

monocytes

HIGH Viral or fungal infections, tuberculosis, some leukemias, other chronic diseases LOW: Bone marrow suppression, treatment with cortisol

basophils

HIGH: allergic reactions, leukemias, cancers, hypothyroidism LOW: pregnancy, ovulation, stress, hypothyroidism

hemoglobin in red blood cells transports

most oxygen and carbon dioxide in the blood

white blood cells function

combats pathogens and foreign substances that invade the body

platelet main funcion

stops bleeding, releases chemical that causes vascular spasm and blood clotting

bone marrow transplants

are performed to replace cancerous red bone marrow with normal red bone marrow

donor's bone marrow usually collected from the

iliac crest of the hip bone

Hemostasis is a sequence of responses that

stop bleeding (in a vessel)

The 3 steps of hemostasis

The process involves: 1. Vascular spasm 2. Platelet plug formation 3. Blood clotting (coagulation)

blood clotting can be activated in these two ways

Extrinsic pathway Intrinsic pathway The extrinsic pathway is activated by external trauma that causes blood to escape from the vascular system. ... The intrinsic pathway is activated by trauma inside the vascular system, and is activated by platelets, exposed endothelium, chemicals, or collagen. Both of these pathways lead to the formation of prothrombinase and, from there, the common pathway continues.

What vitamin is needed for normal clot formation?

Vitamin K is needed for normal clot formation because it is used in the synthesis of 4 clotting factors

anemia

Anemia is a condition where the oxygen carrying capacity of blood is reduced due to a decreased number of RBCs or a decreased amount of hemoglobin

sickle-cell disease

Sickle cell disease (SCD) is a genetic anemia (oxygen-carrying capacity of the blood is reduced) CHANGED SHAPE OF CLOOD INTO CRESCENT* The red blood cells of individuals with this disease contain hemoglobin-S (Hb-S), which causes red blood cells to bend into a sickle shape when it gives up oxygen to the interstitial fluid

Hemophilia

Hemophilia is an inherited deficiency of clotting in which bleeding may occur spontaneously or after minor trama

Leukemia

Leukemia is a group of red bone marrow cancers in which abnormal white blood cells multiply uncontrollably Types include acute lymphoblastic leukemia (ALL), acute myelogenous leukemia (AML), chronic lymphoblastic anemia (CLA), chronic myelogenous leukemia (CML)

how many blood groups are there?

how is blood categorized? (4 groups)

A, B, or AB, with O being the absence of the antigens