Week 5 Flashcards
1
Q
List 5 types of chemical mediators
A
- Histamines
- Prostaglandins
- Cytokines
- Serotonin
- Nitric Oxide
2
Q
Name the 3 places Histamines are stored
A
- Mast Cells
- Basophils
- Platelets
3
Q
List 3 things Histamine triggers
A
- Allergens
- Trauma
- Temperature
4
Q
Which 3 cells utilise Prostaglandins?
A
- Macrophages
- Endothelial
- Leukocytes
5
Q
List 3 things Prostaglandins triggers
A
- Trauma
- Certain chemicals
- Certain physical
6
Q
List 5 effects of Prostaglandins
A
- Vasodilation
- Produce fever
- Inhibit stomach acid secretion
- Smooth muscle constriction
- Uterine muscle relaxation
7
Q
What are NSAIDs?
A
Non-Steroidal Anti-Inflammatory Drugs
8
Q
What do NSAIDs do?
A
- Inhibit COX enzymes that are responsible for adverse effects
- Inhibit COX-1 enzymes in stomach -> removes protective effects, results in GI mucosa damage
- Inhibit COX-2 enzymes in peripheral tissues will reduce pain and inflammation
9
Q
List 3 adverse effects of NSAIDs
A
- Irritation of gastric mucosa
- Increases secretion of hydrochloric acid
- Prolonged bleeding times
10
Q
List 5 effects of H1 receptors
A
- Increased permeability
- Vasodilation
- Appetite suppression
- Contraction
- Pain and itching sensations
11
Q
List 5 effects of H2 receptors
A
- Increased gastric acid secretion
- Vasodilation
- Relaxation
- Control of fluid balance
- Modulation of immune function
12
Q
What can serotonin be used to treat?
A
- Anxiety
- Depression
13
Q
What does nitric oxide do?
A
Helps maintain homeostasis
14
Q
What are cytokines used for?
A
- Autoimmune conditions
- Transplant
