Week 4 - Kidney Failure Flashcards
What are the 2 types of nephrons?
Cortical nephrons
Juxtamedullary nephrons
What is the funciton of the renal corpuscle and tubular system of nephron?
Renal corpuscle = site of initial blood filtration
Tubular system = controls concentration and content of urine
What are the blood supplies to the nephron?
Glomerulus capillary bed - in Bowman’s capsule - high hydrostatic pressure - FILTRATION
Peritubular capillary bed - aroudn tubular system - low hydrostatic pressure - REABSORPTION AND SECRETION
What is GFR?
Volume of fluid entering Bowman’s capsule per unit time
What does the glomerular filter look like?
What is the organisatino of golumerular capillary membrane?
What are the effects of afferent arteriole constriction, efferent arteriole constriction and hypoproteinaemia on GFR?
Afferent constriction = - GFR
Efferent constriction = + GFR
Hypoproteinaemia = + GFR
What are the benefits of using inulin to estimate GFR?
- Freely filtered
- Not reabsorbed, secreted or metabolised by kidney
- No effect on renal function
- Easily measured in urine
What is RPF?
Renal plasma flow = amount of plasma that perufses kidney per unit time
How do you derive renal bloodflow using RPF?
RBF = RPF / 1 - haematocrit
What is the filtration fraction?
What does high FF indicate?
The proportion of plasma that forms filtrate
+ FF = + colloid osmotic pressure in peritubular capillaries
What are the ways autoregulation alters GFR?
Myogenic - afferent arteriole contraction
Tubuloglomerular feedback - NaCl concentration in filtrate sensed by macula densa of JGA and singal produced, contractin afferent arterioles
What is the juxtaglomerular apparatus?
What is its role?
Macula densa + granular cells
Autoregulation and renin release
What effect do vasodilators and NSAIDs have on RBF and GFR?
Vasodilators = increase RBF and GFR (prostaglandins)
NSAIDs = block prostaglandin synthesis = + vasoconstriction and ischaemia = actue renal tubular necrosis
What is glycosuria?
What causes it?
When renal glucose threshold (RTG) is exceeded, glucose excreted in urine
- Untreated diabetes
- Hyperthyroidism
- Pregnancy
- Familial
- Drugs