week 2 extra Q's Flashcards
Which of the following is hypersensitivity reactions take days to weeks to develop?
a. type I
b. type II
c. type III
d. type IV
d. type IV
cell-mediated
Hypersensitivity mediated cytotoxic reactions to RBC’s are usually which type of reaction?
a. type I
b. type II
c. type III
d. type IV
b. type II
Which of the following structures causes transfusion reaction of RBC’s?
a. glycocalyx
b. glycoproteins
c. lipids
b. glycoproteins
Which of the following results in intravascular hemolysis?
a. immediate transfusion reaction
b. delayed transfusion reaction
a. immediate transfusion reaction
Which of the following is caused by ABO compatible blood?
a. immediate transfusion reaction
b. delayed transfusion reaction
b. delayed transfusion reaction
Which of the following results in shock?
a. immediate transfusion reaction
b. delayed transfusion reaction
a. immediate transfusion reaction
Which of the following results in extravascular hemolysis?
a. immediate transfusion reaction
b. delayed transfusion reaction
b. delayed transfusion reaction
Which of the following is mediated by complement proteins?
a. autoimmune hemolytic anemia
b. drug-induced hemolytic anemia
c. hemolytic disease of the newborn
b. drug-induced hemolytic anemia
Which of the following is administered to the mother to prevent hemolytic anemia?
a. Rh antibodies
b. anti-Rh antibodies
c. anti-anti-Rh antibodies
d. anti-anti-anti-anti-anti-Rh antibodies
b. anti-Rh antibodies
aka Rhogam
In which of the following tests do we test the fetal blood?
a. direct coomb’s test
b. indirect coomb’s test
c. both
a. direct coomb’s test
In which of the following tests do we test antibody titer?
a. direct coomb’s test
b. indirect coomb’s test
c. both
b. indirect coomb’s test
Which of the following results in free hemoglobin in the blood?
a. intravascular hemolysis
b. extravascular hemolysis
c. both
a. intravascular hemolysis
Which of the following usually increases levels of urinary hemosiderin?
a. intravascular hemolysis
b. extravascular hemolysis
c. both
a. intravascular hemolysis
Which of the following is commonly characterized by pigmented gall stones?
a. hereditary spherocytosis
b. hereditary elliptocytosis
a. hereditary spherocytosis
Which of the following is commonly characterized by pencil-like RBC’s?
a. hereditary spherocytosis
b. hereditary elliptocytosis
c. G6PD deficiency
b. hereditary elliptocytosis
Which of the following is recessive?
a. hereditary spherocytosis
b. hereditary elliptocytosis
c. G6PD deficiency
c. G6PD deficiency
X linked
Which of the following is commonly characterized by helmet cells?
a. hereditary spherocytosis
b. hereditary elliptocytosis
c. G6PD deficiency
c. G6PD deficiency
alpha-globin genes are found in which chromosome?
a. chromosome 9
b. chromosome 11
c. chromosome 16
d. chromosome 18
c. chromosome 16
Which of the following diseases is caused by qualitative defects in globin chain production?
a. thalassemia
b. sickle cell anemia
b. sickle cell anemia
Which of the following is commonly characterized by RBC’s with no pallor?
a. hereditary spherocytosis
b. hereditary elliptocytosis
c. G6PD deficiency
d. thalassemia
a. hereditary spherocytosis
Which of the following is commonly characterized by RBC’s with a bigger pallor?
a. hereditary spherocytosis
b. G6PD deficiency
c. thalassemia trait
d. thalassemia major
c. thalassemia trait
Which of the following is commonly characterized by microcytic hypochromic anemia, nucleated, and destroyed RBC’s?
a. hereditary spherocytosis
b. G6PD deficiency
c. thalassemia trait
d. thalassemia major
d. thalassemia major
Which of the following does a child with dental mal-occlusion and “hair on end” appearance most likely have?
a. hereditary spherocytosis
b. G6PD deficiency
c. thalassemia trait
d. thalassemia major
d. thalassemia major
beta-globin genes are found in which chromosome?
a. chromosome 9
b. chromosome 11
c. chromosome 16
d. chromosome 18
b. chromosome 11
Which of the following diseases is caused by quantitative defects in globin chain production?
a. thalassemia
b. sickle cell anemia
c. G6PD deficiency
a. thalassemia
Which of the following globins are affected by a mutation in sickle cell disease?
a. alpha
b. beta
c. gamma
d. delta
b. beta
Which of the following describes the RBC size of sickle cell disease?
a. macrocytic
b. microcytic
c. normocytic
c. normocytic
free plasma hemoglobin S inactivates nitric oxide, which if the following does this lead to?
a. jaundice
b. gallstones
c. thrombosis
d. nephropathy
c. thrombosis
(nitric oxide inhibits adhesion molecules, without this, adhesion molecules accumulate & blood clots may occur; this was said in class)
Why is hydroxyurea used to treat sickle cell?
a. causes fewer mutations on the sickle cell gene
b. prevents folate deficiency
c. reduces hemoglobin S synthesis
d. increases hemoglobin F synthesis
d. increases hemoglobin F synthesis
hemoglobin F in RBC’s reduces polymerization
Sickle cell trait comes with an increased risk of
a. renal medullary carcinoma
b. renal cortical carcinoma
c. renal cell carcinoma
d. invasive ductal carcinoma
a. renal medullary carcinoma
Which of the following has an increase in alpha chains?
a. alpha thalassemia
b. beta thalassemia
b. beta thalassemia
Which of the following can lead to death in thalassemia major?
a. high blood viscosity
b. blood clots
c. iron overload
c. iron overload
What best describes thalassemia intermedia?
a. one beta-globin gene affected
b. both beta-globin genes affected
b. both beta-globin genes affected
Which of the following occurs when two alpha genes are defective?
a. silent carrier
b. alpha thalassemia minor
c. hemoglobin H disease
d. hydrops fetalis
b. alpha thalassemia minor
T/F: thalassemia intermedia is transfusion independent
true
Which of the following occurs when all alpha genes are defective?
a. silent carrier
b. alpha thalassemia minor
c. hemoglobin H disease
d. hydrops fetalis
d. hydrops fetalis (HB Barts)
Which of the following causes RBC’s to have a golf ball appearance?
a. silent carrier
b. alpha thalassemia minor
c. hemoglobin H disease
d. hydrops fetalis (HB Barts)
c. hemoglobin H disease