2015 module exam Flashcards
Which mutation is found in HbSS?
A) glu6val
B) glu26val
C) glu6lys
A) glu6val
How many alpha mutations are in HbH hemoglobin?
A) 2
B) 3
C) 4
B) 3
Hb Bart's Hydrops fetalis syndrome results from deletions of how many and what type of globin? A) 4, gamma globin B) 4, alpha globin C) 4, beta globin D) 2, gamma globin
B) 4, alpha globin
In HPFH, the switch from what to what is impaired? A) gamma to beta B) alpha to beta C) epsilon to gamma D) alpha to gamma
A) gamma to beta
HPFH= Hereditary Persistence of Fetal Hemoglobin
A patient underwent hypoxia while having an already-existing renal disease. Which hematopoietic cell decreases in this condition? A) Neutrophils B) Lymphocytes C) Monocytes D) Proerythroblasts
D) Proerythroblasts
what drug is used to prevent myelosuppression and mucositis during treatment with antimetabolites? A) MTX B) cytosine arabinoside C) leucovorin D) 6 – mp
C) leucovorin
Which of the following molecules is associated with lipid rafts?
A) Sphingomyelin
B) AE1 transporters
C) Glut1
A) Sphingomyelin
Which of the following molecules activates FXII? A) Kallikrein B) HMW kininogen D) Pre-kallikrein E) Hagemanfactor
A) Kallikrein
Which of the following is responsible for T cell death upon its presentation to a self- antigen?
A) Positive selection
B) Negative selection
C) ADCC
B) Negative selection
Which of the following immunoglobulins results in hemorrhagic disease of the newborn? A) IgM B) IgA C) IgG D) IgE
C) IgG
In a man with Hereditary spherocytosis, which of the following is expected? A) high conjugated bilirubin B) gallstone C) low reticulocytes D) hypocellular BM
B) gallstone
What blood type combination would cause hemolytic disease of the newborn?
A) Rh+ dad Rh- mom
B) Rh+ dad and Rh+ mom
C) Rh- dad Rh+ mom
A) Rh+ dad Rh- mom
A patient just came in from road traffic accident, what will you give him?
A) Packed RBC when 2 liters of blood is lost
B) FFP as a volume expander of blood
C) Packed RBC when 10% of his blood is lost
A) Packed RBC when 2 liters of blood is lost
What happens if you give IgA to an IgA deficient recipient?
A) Bacterial contamination
B) Graft vs host disease
C) Anaphylactic reaction
D) delayed hemolytic transfusion reaction
C) Anaphylactic reaction
What is reduced with gamma irradiation? A) Graft vs host disease B) Bacterial contamination C) Viral infections D) Acute hemolytic transfusion reaction
A) Graft vs host disease
What would be the strongest evidence to suggest iron-deficiency anemia?
A) Low transferrin saturation
B) Low hemosiderin
C) Low serum iron
A) Low transferrin saturation
A patient came with severe blood loss and there was no time to type his blood type. What blood group can be used immediately in this emergency? A) A + B) O- C) O+ D) AB+
B) O-
How do you store platelets?
A) 20C, 5 days
B) 20C, 30 days
C) -20 C, 5 days
A) 20C, 5 days
If a person has a blood group A then which antibodies are present in that person's blood? A) anti-A antibodies B) anti-B antibodies C) anti-O antibodies D) anti-H antibodies
B) anti-B antibodies
There are few different markers that we use in the clinic to assist our differential to microcytic anemia. Which of the following types would have a reduced ferritin level? A) Myelodysplasia B) Anemia of chronic disease C) Sideroblastic anemia D) Thalassemia E) Iron deficiency anemia
E) Iron deficiency anemia
Which of the following fusion protein would result in the development of chronic myeloid leukemia?
A) P190
B) P210
C) P230
B) P210
In hypersensitivity type II, which of these mechanisms results in RBCs destruction? A) ADCC B) Major cationic proteins C) Perforin D) Phagocytosis
A) ADCC
What is the factor used to initiate the intrinsic pathway if we want to make the reaction in a tube (in vitro)? A) prothrombin B) factor Xa C) factor XIIIa D) factor V E) factor XIIa F) factor VII
E) factor XIIa
Which of the following is an oral anticoagulant with rapid action but short half-life?
A) Heparin
B) Otamixaban
B) Otamixaban
Otamixaban is administered by IV, so this is probably wrong.
In a patient with septicemia, prolonged APTT and PT, low platelets and fibrinogen, what diagnostic test is performed next?
A) D dimer
B) Blood test
A) D dimer
Patient with MI was given anticoagulants, what would be a reason for alarm? A) purpura B) high creatinine C) body weight D) history of jaundice E) rash F) nausea
A) purpura
A woman came to the clinic with a mottled purple leg. She had a previous miscarriage and her APTT was high. What could her diagnosis be?
A) antiphospholipid syndrome
B) DIC
C) TTP
A) antiphospholipid syndrome
Which of the following is a transfusion hazard associated with platelets transfusion? A) TRALI B) Bacterial contamination C) Febrile non-hemolytic reaction D) Graft vs host hemolysis E) Delayed reaction hemolysis F) Anaphylactic reaction
B) Bacterial contamination
40 y/o male with spontaneous gum swelling and bleeding. CBC: low Hb, low Plt, Normal WBC
PBS: circulating immature cells
What is the most useful investigation to help in diagnosis?
A) Morphology of BM aspirate
B) immunophenotyping of PB lymphocytes
C) Reticulocyte counts
A) Morphology of BM aspirate
Which of the following is a tyrosine kinase inhibitor?
a. clopidogrel
b. imantinib
b. imantinib
What component if exposed on the outer aspect of the RBC will lead to the removal of the RBC from the circulation? A) Phosphatidylserine C) Ankyrin D) Spectrin E) Actin F) Phosphatidylcholine G) Sphingomyelin
A) phosphatidylserine
Which leukemia is more likely to present with an abnormal tyrosine kinase activity? A) CLL B) ALL C) AML D) CML
D) CML
What is the mechanism of action of heparin?
A) direct inhibitor of factor 10A
B) increases activity of antithrombin III
C) direct inhibitor of thrombin
B) increases activity of antithrombin III
what is involved in suppressing trilineage hematopoiesis activity in tuberculosis?
A) colony-stimulating factors (CSFs)
B) IL (interleukins)
C) TNF (tumor necrosis factor)
C) TNF (tumor necrosis factor)
