Week 2 Flashcards

1
Q

two signals can travel into the cell body

A

excitatory and inhibitory signals

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2
Q

excitatory signals

A

cell more likely to fire

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3
Q

inhibitory signals

A

cell less likely to fire

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4
Q

signal reaches axon hillock

A

summation occurs

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5
Q

summation?

A

sum of all incoming signals determines whether the neuron fires

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6
Q

threshold to fire?

A

-55mV

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7
Q

beginning value of the neuron

A

-70mV

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8
Q

resting membrane potential

A

when the cell is more negatively charged compared to outside the cell

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9
Q

ions crucial to sending signal down an axon

A

Potassium K+ and Sodium Na+

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10
Q

When the K+ is pulled in both directions

A

the cell is at rest

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11
Q

action potential

A

change in voltage in the cell, taking place at one section of the cell at a time

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12
Q

Volted gated sodium channels

A

doorway triggered by certain electrical charge - they open at -55mV

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13
Q

Propagation

A

process of the sodium gates opening

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14
Q

water outside vs inside the cell

A

salty water vs different kind of water with particles in it

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15
Q

Ion channels

A

allow specific ions through

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16
Q

Fundamental properties of how ions move

A

concentration gradient and electrical gradient

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17
Q

concentration gradient

A

sodium wants to go where there is less of itself until equilibrium occurs

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18
Q

passive diffusion

A

natural process where ions move from high to low concentration till equilibrium occurs without the need for external energy

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19
Q

electrical gradients

A

charged particles will move across the membrane until electrical equilibrium has occured

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20
Q

What does K+ want to do

A

Wants to go out of the cell because there is less K+ out there (CF). Wants to stay in the cell and make it as positive as possible (EF).

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21
Q

Depolarization

A

When the cell becomes crazy positive

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22
Q

When do the sodium channels close

A

at 30mV

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23
Q

Repolarization

A

Takes the mV back to 0, overshoots to -80mV

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24
Q

Refractory period

A

Trying to get back to the resting potential

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25
Sodium/Potassium pump
pushed Na+ outside the cell, brings K+ inside the cell
26
Rules of the pump
Throws 3 Na+ out, brings 2 K+ in And requires energy
27
Saltatory Conduction
Jumping from one Node to the next
28
Benefits of Saltatory Conduction
Signal moves faster, energy efficient
29
Santiago Ramoon y Cajal & Camillo Golgi
worked together on Neurons and had opposing POVs on how they worked - whether they were connected or not
30
Neuronal communication is
Electrochemical
31
Electrical vs chemical
Action potential vs passing info between cells
32
Neurotransmitters travel in
Vesciles
33
Ca2+ essential for
Allowing chemicals in the presynaptic cell to exit the cell and enter the synaptic cleft
34
Cl- essential to
Understand how neurons send inhibitory signals
35
Steps of synaptic transmission
Screenshot answer
36
Ligand gated ion channels
Doors that expect a specific chemical shape & will only open then
37
Reuptake
Pre-synaptic cell membrane has neuro-transmitter-specific 'transporter' proteins that transport neurotransmitters back into the presynaptic cell
38
Neurotransmitters
Chemical messengers; 100+ types
39
Categories of Neurotransmitters
Amino acids, monoamines, peptides
40
Amino acids
Glutamate, GABA
41
Monoamines
Dopamine, serotonin, and histamine
42
Peptides
Endorphins, oxytocin
43
Dopamine
Can be excitatory or inhibitory depending on the doorway
44
Glutamate
Main excitatory neurotransmitter
45
GABA
main inhibitory neurotransmitter
46
Depolarizing the cell
Making it more positive - sodium & calcium used
47
Hyperpolarizes the cell
Makes it more negative - chloride used
48
Reuptake why
Not all the neurotransmitters were needed
49
Dopamine involved in
thoughts feelings motivations behaviours experiences of pleasure attention mood regulation emotional responses coordinating movement
50
Parkinson's disease
Progressive loss of dopamine producing neurons
51
Serotonin involved in
regulation of mood sleep eating arousal pain
52
Agonists
Drugs that occupy receptors & activate them
53
Antagonists
Drugs that occupy receptors, but don't activate them. They block receptor activation by agonists
54
SSRI
Selective serotonin reuptake inhibitor - block the reuptake from taking serotonin back into the cell, stays in the cleft, sends more signals in theory
55
Nervous system
Carries out actions, tells the brain how things feel etc
56
Two parts of the nervous system
Central nervous system and peripheral nervous system
57
Central nervous system
Brain and down the spinal cord
58
Peripheral nervous system
all the nerves that come from the spinal cord & go to fingers, legs etc
59
Neurons/neuronal cells
receive and transmit signals
60
Dendrites
Receive information
61
The cell
receives the info from the dendrites
62
Axon
Carries the info away from the cell
63
Axon terminal/terminal region
Reach out to send info to another cells dendrites
64
Dendritic spines
Extra surface areas where axon terminals can make connections
65
Axon hillock
Keeps count for a signal threshold to be reached
66
Myelin sheaths
Cover the axon, determines whether a signal moves fast down the axon
67
Gaps between myelin sheaths
Nodes of Ranvier
68
Nodes of Ranvier
Cause the signal to jump, makes it faster
69
Glial cells (3 kinds0
Oligodendrocytes, Schwann cells, Astrocytes
70
Oligodendrocytes
form the sheath in the CNS, wraps an arm around the axon, can do this on multiple sections or cells, purpose to increase speed of info
71
Schwann cells
form the sheath in the PNS, they wrap their entire self around the axon, purpose to increase speed of info
72
Astrocytes
help repair neurons, bring nutrients in from the blood stream
73
Astrocytes nutrients how
Use their little feet to create a blood-brain barrier, passes the nutrients through to other cells