week 12- MSK Flashcards
skeleton is composed of 2 tissues
- bone
- cartilage
skeleton is composed of 3 cell types
- osteoblasts
- osteoclasts
- chondrocytes
skeletal tissue derive from 3 embryonic cell lineages
- cranial neural crest
- paraxial mesoderm
- lateral plate mesoderm
CRANIOFACIAL SKELETON, CALVARIUM, MIDFACE, MANDIBLE AND TEETH DERIVE FROM
cranial neural crest cell
axial skeleton derived from
paraxial mesoderm
limbs derive from
lateral plate mesoderm
notochord and neural tube form in week
3
intraembryonic mesoderm lateral to the notochord and neural tube thicken to form 2 longitudinal columns of ____
paraxial mesoderm
appear as bead-like elevations along the dorsolateral surface of the embryo.
somites
somites differentiate into 2 parts:
- ventromedial part
2. dorsolateral part
ventromedial part is the ___ and ___
sclerotome vertebra and ribs
dermomyotome from the
- myoblasts (muscle cells)
- dermis (fibroblasts)
dorsolateral part
neural plate fuse to form the neural tube and is made from
ectoderm
limb buds start to develop in week 6, as clusters of ___ cells covered by ___
mesenchymal
ectoderm
Limbs develop in a ____ sequence
proximodistal
the __and ___ form first, followed by ___ and ___, ___ and ___, metacarpal and matatarsal, and finally phalanges
- humerus & femur
- radius & ulna
- tibial & fibula
osteogenesis begins in the __ and ___ by 8 weeks
clavicle & mandible