Week 11 - Urinary System Flashcards
4 organs of the urinary system
Kidneys
ureters
urinary bladder
urethra
Functions of the urinary system
Excretion
Elimination
Homeostatic regulation
Through what blood vessel does the kidneys receive blood
Renal artery
2 sympathetic innervations
- Adjusts rate of urine formation
- Influences urine composition
Define nephrons
Microscopic functional units of kidneys
three metabolic wastes
urea
creatine
Uric acid
kidneys function
concentration filtrate
Reabsorption and retention of valuable materials
Basic process of urine formation
Filtration
Reabsorption
Secretion
2 factors that govern glomerular filtration
Hydrostatic pressure
Colloid osmotic pressure
Define glomerular hydrostatic pressure (GHP)
Blood pressure in glomerular capillaries
Function of Capsular hydrostatic pressure (CsHP)
- Opposes glomerular hydrostatic pressure
- Pushes water and solutes out of filtrate
Define net hydrostatic pressure
- Difference between glomerular hydrostatic pressure and capsular hydrostatic pressure
GHP - CsHP = NHP
Define colloid osmotic pressure
Pressure due to materials in solution
Glomerular filtration rate
125 mL/min
3 methods of GFR regulation
- Autoregulation (local level)
- Hormonal regulation (initiated by kidneys)
- Autonomic regulation (by sympathetic division of ANS)
What protein is released at the juxtaglomerular complex (JGC)
Renin
Solutes that enter the capsular space
- Metabolic wastes and excess ions
2. Glucose, free fatty acids, amino acids and vitamins
Reabsorption and secretion involve what 4 factors
- Diffusion
- Osmosis
- Leak channels
- Carrier - mediated transport
Define transport maximum (T m)
If nutrient concentrations rise tubular fluid, reabsorption rates increase until carrier proteins are saturated
Define renal threshold
Plasma concentration at which a specific compound or ion begins to appear in urine
Functions of proximal convoluted tubule
Reabsorption of organic nutrients Active reabsorption of ions Reabsorption of water Passive reabsorption of ions Secretion
Function of descending limb of nephron looop
- Freely permeable to water but not to solutes
Reabsorbs sodium and chloride
Function of ascending limb of nephron loop
- Impermeable to water
- Passively and actively removes sodium and chloride ions
three functions of the distal convoluted tubule
Active secretion of ions, drugs, acids and toxins into tubule
Selective reabsorption sodium and calcium ions
Selective reabsorption of water
Define hypokalemia
Dangerous reduction in plasma potassium ion concentration
Parathyroid hormone function
Regulates calcium ion reabsorption at DCT
In response to acidosis
Ammonium ions are pumped into tubular fluid
Define countercurrent multiplication
Exchange between fluids moving in opposite directions
Water is reabsorbed where?
PCT
Descending limb
When does water reabsorption occur
when osmotic concentration of peritubular fluid exceeds that of tubular fluid
Function of Antidiuretic hormone (ADH)
Increases rate of osmotic water movement
Define countercurrent exchange
Vasa recta returns reabsorbed solutes and water to general circulation
Define ureters
Muscular tubes that extend from kidneys to urinary bladder
Function of urethra
- Transports urine from neck of urinary bladder to exterior of body
Define incontinence
Inability to control urination voluntarily