Week 1 PP Flashcards
By ethnicity & sex which are most likely to die from heart disease…
Black Most Deaths for Males & Females
White male most likely
1 in 2 men
1 in 3 women
Will die of HD befire age 40
T or F
T
Percent of deaths caused by heart disease
25%
Risk factors for heart disease (5)
Weight
BP
Glucose
Cholesterol
Tobacco
In USA about how many die from Heart Disease annually…
1 million
Half men / Half women
Most fatal type of cardiovascular disease
Coronary Heart Disease
Most likely age group to die from cardiovascular disease…
80+
Blood flow through the heart
How & where does Unoxygenated blood enter the heart?
Superior Vena cava Upper Body
Inferior vena cava Lower Body
Blood flow through the heart
- Unoxygenated blood enters (this portion of the heart) ___ from the Superior & Inferior Vena Cava
- After it travles through this valve.
- Unoxygenated blood in the right ventricle is then sent to the lungs. Through this Valve & this blood vessels…
- Blood is sent back from the lungs via this blood vessels…
- Oxygenated blood reaches this part of the heart first…
- Then, oxygenated blood is sent through this valve to this part of the heart.
- Finally oxygenated blood is sent through this valve & blood vessel to be distributed to the body.
- Right Atrium
- Tricuspid
- Pulmonary Valve & Pulmonary Artery (Unoxygenated)
- Pulmonary Vein
- Left atrium
- Mitral / bicuspid valve & Left Ventricle
- Aortic valve / aorta
The Aorta has 3 arteries that extend from it.
Name them & their function
Starting most leftward
Left subclavian
Supply oxygen-rich blood to the upper body, including the left arm, neck, head, and part of the brain
Left common carotid artery (LCCA)
Supplies oxygen-rich blood to the head and neck, including the brain
Brachiocephalic
Carry oxygenated blood to the upper right side of the body, specifically supplying blood to the right arm, head, and neck.
Brachiocephalic branches into 2 arteries.
The right subclavian artery (for the arm)
Right common carotid artery (for the head and neck).
Purpose of Chordea Tendineae
Attaches to the Atrioventricular Valves (AV) and prevents them from prolapsing into the Atrium with contractions
Accomplished by anchoring the Valve leaflets to the papilary muscles.
Located near the temples on the side of the head.
Supplies blood to parts of the forehead and scalp.
Used to assess a pulse in infants or when other sites are inaccessible.
Temporal Artery
Found on both sides of the neck.
Supplies oxygenated blood to the brain, neck, and face.
Commonly checked during CPR for pulse assessment.
Carotid Artery
Not an artery but refers to the heartbeat heard over the apex of the heart using a stethoscope.
Reflects the left ventricular contraction.
Assessed for irregularities in rhythm or rate.
Apical Pulse (Heart)
Runs along the upper arm.
Supplies blood to the arm and hand.
Used to measure blood pressure or pulse in infants.
Brachial Artery
Located on the thumb side of the wrist.
Supplies blood to the forearm and hand.
Common site for measuring pulse in adults.
Radial Artery
Found in the groin area.
Supplies blood to the lower abdomen, thighs, and legs.
Checked during trauma or emergencies to assess circulation to the lower body.
Femoral Artery
Located behind the knee.
Supplies blood to the knee joint, thigh, and calf.
Assessed for circulation in the lower leg.
Popliteal Artery
Runs along the inner side of the ankle.
Supplies blood to the foot.
Checked to assess circulation to the foot.
Posterior Tibial Artery
Located on the top of the foot.
Supplies blood to the foot and toes.
Assessed to evaluate peripheral circulation, particularly in patients with vascular disease.
Pedal (Dorsalis Pedis) Artery
Types of Semilunar Valves:
_________
Located between the right ventricle and the pulmonary artery.
Prevents backflow of blood from the pulmonary artery into the right ventricle during diastole (heart relaxation).
______
Located between the left ventricle and the aorta.
Prevents backflow of blood from the aorta into the left ventricle during diastole.
Pulmonary Valve
Prevents backflow of blood from the pulmonary artery into the right ventricle during diastole (heart relaxation).
Aortic Valve
Located between the left ventricle and the aorta.
Prevents backflow of blood from the aorta into the left ventricle during diastole.
Composed of three cusps (or leaflets).
Open during ventricular systole (contraction) to allow blood to flow out of the heart.
Close during ventricular diastole to prevent blood from flowing back into the heart.
Semilunar Valves
Pulmonary & Aortic Valve
Cardiac Conduction System
Location: Upper right atrium, near the opening of the superior vena cava.
Function:
Acts as the heart’s natural pacemaker.
Initiates electrical impulses that set the heart’s rhythm (normal rate: 60–100 beats per minute).
Causes the atria to contract, pushing blood into the ventricles.
Sinoatrial (SA) Node
Sinoatrial (SA) Node
Location….
Function… (3)
Location:
Upper right atrium, near the opening of the superior vena cava.
Function:
Acts as the heart’s natural pacemaker.
Initiates electrical impulses that set the heart’s rhythm (normal rate: 60–100 beats per minute).
Causes the atria to contract, pushing blood into the ventricles.
Electrical Conduction System
____________
Location: Lower part of the right atrium, near the interatrial septum.
Function:
Receives impulses from the SA node and delays them slightly.
This delay allows the ventricles to fill with blood before contracting.
Passes the impulses to the bundle of His.
Atrioventricular (AV) Node
Electrical Conduction System
Atrioventricular (AV) Node
Location…..
Function…. (3)
Location
Lower part of the right atrium, near the interatrial septum.
Function
Receives impulses from the SA node and delays them slightly.
This delay allows the ventricles to fill with blood before contracting.
Passes the impulses to the bundle of His.
Electrical Conduction System
___________
Location: Runs from the AV node through the interventricular septum.
Function:
Transmits electrical impulses from the AV node to the ventricles.
Divides into the left and right bundle branches for each ventricle.
Bundle of His (Atrioventricular Bundle)
Electrical Conduction System
Bundle of His (Atrioventricular Bundle)
Location….
Function….. (2)
Location
Runs from the AV node through the interventricular septum.
Function
Transmits electrical impulses from the AV node to the ventricles.
Divides into the left and right bundle branches for each ventricle.
Electrical Conduction System
_______________
Location: Extend from the bundle of His along the interventricular septum.
Function:
Conduct impulses to the left and right ventricles.
Ensure synchronized contraction of both ventricles.
Left & Right Bundle Branches
Electrical Conduction System
Left and Right Bundle Branches
Location…..
Function….. (2)
Location:
Extend from the bundle of His along the interventricular septum.
Function:
Conduct impulses to the left and right ventricles.
Ensure synchronized contraction of both ventricles.
Electrical Conduction System
________
Location: Spread throughout the walls of the ventricles.
Function:
Distribute electrical impulses to the ventricular muscle cells.
Trigger the ventricles to contract, pumping blood to the lungs (via the right ventricle) and the rest of the body (via the left ventricle).
Purkinje Fibers
Electrical Conduction System
Purkinje Fibers
Location….
Function……
Location:
Spread throughout the walls of the ventricles.
Function:
Distribute electrical impulses to the ventricular muscle cells.
Trigger the ventricles to contract, pumping blood to the lungs (via the right ventricle) and the rest of the body (via the left ventricle).
SA Node → 2. _____ contract → 3. AV Node → 4. Bundle of His → 5. Bundle Branches → 6. Purkinje Fibers → 7. ______ contract.
SA Node → 2. Atria contract → 3. AV Node → 4. Bundle of His → 5. Bundle Branches → 6. Purkinje Fibers → 7. Ventricles contract.
Function: Supplies oxygenated blood to the left side of the heart, including the left atrium and ventricle.
Left Coronary artery
Left Coronary Artery
Branches:
Left Anterior Descending (LAD) Artery:
Circumflex (Cx) Artery:
Left Anterior Descending
Supplies blood to the front of the left ventricle and the interventricular septum.
Critical for maintaining function in the heart’s pumping chambers.
Circumflex Artery:
Supplies blood to the left atrium and the side and back of the left ventricle.
_____________
Function: Supplies oxygenated blood to the right side of the heart, including the right atrium, right ventricle, and parts of the conduction system.
Branches:
Right Marginal Artery:
Supplies the right ventricle.
Posterior Descending Artery (PDA):
Supplies blood to the bottom part of the ventricles and the back of the interventricular septum.
Right Coronary Artery
Cardiac output range
4 / 8 L per minute
Cardiac Output depends on….
HR × SV
Heart rate times Stroke Volume
Volume of blood ejected by the left ventricle per beat (normal: ~70 mL/beat).
Normal HR Adult
60 - 100
Which nervous system controls the HR
Autonomic
Stroke volume (SV) is the amount of blood ejected by the ____ ventricle with each heartbeat.
It is influenced by several factors:
Left Ventricle
HR, Preload, Afterload, contractility
Explain HR relationship with SV
At high heart rates, stroke volume may decrease because there is less time for ventricular filling (diastole).
A balanced heart rate allows optimal ventricular filling and maximum stroke volume.
At high heart rates, stroke volume may decrease because there is less time for ventricular filling aka…..
Ventricular emptying aka…
(diastole)
Systole
Afterload:
Definition: The resistance the ventricles must overcome to eject blood during systole.
Relationship to SV:
Increased afterload ….
Decreased afterload….
Increased Afterload:
(e.g., in hypertension or aortic stenosis): Makes it harder for the heart to pump blood, reducing stroke volume.
Decreased afterload:
Reduces the resistance, allowing the ventricles to eject blood more easily, increasing stroke volume.
Define:
- The resistance the ventricles must overcome to eject blood during systole.
- The degree of stretch of the ventricular walls at the end of diastole, before contraction.
- Afterload
- Preload
Contractility:
Definition: The strength of the heart’s contraction, independent of preload and afterload.
Relationship to SV:
Increased contractility….
Decreased contractility
Increased contractility (e.g., from sympathetic stimulation or inotropic drugs): Enhances the force of contraction, increasing stroke volume.
Decreased contractility (e.g., in heart failure or myocardial ischemia): Weakens the contraction, reducing stroke volume.
_____ = Preload (↑) + Contractility (↑) - Afterload (↓)
Stroke Volume (SV)
Ejection Fraction (EF) is….
Percentage that reflects the efficiency of the heart’s pumping ability
Specifically the proportion of blood pumped out of the left ventricle with each heartbeat.
It is a key indicator of heart function, especially in diagnosing heart conditions such as heart failure.
StrokeVolume ÷ End-DiastolicVolume
× 100 =
Ejection Fraction
Determined by left ventricular end-diastolic volume
Preload
Degree of myocardial fiber stretch at the end of diastole…
Preload
Starling’s law is associated with Preload
Define…
More the heart is filled during diastole the more forcefully it contracts.
(Upto a point)
Preload
Excessive filling = Excessive Left Ventriclar End-Diastolic Volume - (LVEDV) = Overstretched = (High/ Low) Cardiac Output
Low CO
Pressure ventricles must overcome to eject blood into the peripheral blood vessels
Define….
Afterload
Afterload
Pressure ventricles must overcome to eject blood into the peripheral blood vessels
Is influenced by this valve….
Aortic
Increased demand to meet tissues metabolic needs will have this effect on blood vessels & blood pressure….
Vasodilation in active tissues, which increases blood flow.
Cardiac output increases to meet this demand, leading to a temporary increase in systolic blood pressure while diastolic pressure may remain unchanged or decrease slightly.
Force exerted against the blood vessels wall is…
Blood pressure
Autonomic NS & _____ regulate blood pressure
Kidneys
Autonomic NS (Sympathetic/ Parasympathetic)
Have these types of sensory receptors….
Chemo: respond to chemical changes ie. Hypoxemia
Baroreceptors: Respond to pressure
Stretch receptors: Sense low blood volume
Autonomic NS
Location:
Chemoteceptors
Baroreceptors
Stretch receptors
Chemoteceptors: Aortic arch & Carotid bodies
Baroreceptors: Aortic Arch & Carotid sinus
Stretch receptors: Vena Cava & Right Atrium
Affects of Alpha ¹ & Beta ¹ response in the sympathetic NS.
A¹ = Vasoconstriction = Increased BP
B¹ = Increased HR, AV Conduction, Contractility
Renal system does what when BP decreases…
Hold Sodium & Water
They renal system may activate this in response to low bp…
RAAS
Renin-Angiotensin-Aldostrone system
Increases Fluid / Blood Volume, increasing BP
Renal system to combat hypotension…
- _____ release triggers the conversion of angiotensinogen to angiotensin I, which is then converted to angiotensin II.
- Angiotensin II causes ____ and stimulates aldosterone release, leading to sodium and water retention in the kidneys.
- Renin
- vasoconstriction
Renal System Influencing factors
Antidiuretic hormone
Increase BP
Causes kidney to reabsorp H2O
Renal System Influencing factors
Natriuretic peptides
Lowers BP
Diuresis & Renal Vasodilation
Bradykinin & Histamine
Affect on BP…
Vasodilation Lower BP
Increase capillary permeability
Name the 3 main arteries located on the heart.
Left Anterior Descending
Right Coronary Artery
Circumflex
Which part of BP does blood flow…
Systolic (Primary)
What often causes a heart murmur ( a sound heard between heart beats)
Blood flowing through a restriction
Ie. Aortic stenosis/ mitral stenosis
Labs
Creatine Kinase (CK):
Normal Values…
Relevance…
Men: 38–174 U/L
Women: 26–140 U/L
Relevance: CK levels rise in muscle damage, including cardiac or skeletal injury. Non-specific for heart conditions.
Labs
Creatine Kinase-MB (CK-MB):
Normal Values….
Relevance….
Critical Values…
Norms:
0–7 ng/mL or 0–5% of total CK.
Relevance:
CK-MB rises 3–6 hours after a heart attack, peaks at 12–24 hours, and returns to normal within 48–72 hours.
Critical Values:
Levels greater than 10 ng/mL strongly suggest myocardial infarction.
Labs
Lactate Dehydrogenase (LDH):
Normal Values….
Relevance…
Critical Values…
Normal Values: 140–280 U/L (varies by lab).
Relevance: LDH levels rise in tissue damage, including the heart. LDH-1 and LDH-2 isoenzymes are heart-specific, with LDH-1 > LDH-2 often indicating myocardial infarction.
Critical Values: LDH levels >400 U/L may indicate significant tissue injury.
Troponin (I and T):
Normal Values:
Troponin I…
Troponin T…
Relevance….
Critical Values…
Troponin (I and T):
Normal Values:
Troponin I: <0.04 ng/mL.
Troponin T: <0.01 ng/mL.
Relevance: Troponin rises 4–6 hours after myocardial injury, peaks at 12–24 hours, and remains elevated for 7–10 days.
Critical Values: Levels >0.40 ng/mL strongly indicate a myocardial infarction.
Natriuretic Peptide (BNP):
Normal Values….
Relevance….
Critical Values…..
Natriuretic Peptide (BNP):
Normal Values: <100 pg/mL.
Relevance: Elevated BNP indicates heart failure severity. Levels >400 pg/mL are highly suggestive of heart failure, while 100–400 pg/mL warrants further investigation.
Critical Values: >900 pg/mL is associated with severe heart failure.
Homocysteine:
Normal Values….
Relevance…..
Critical Values….
Homocysteine:
Normal Values: 4–15 µmol/L.
Relevance: Levels >15 µmol/L indicate an increased risk of atherosclerosis and cardiovascular disease.
Critical Values: Levels >30 µmol/L suggest severe risk for vascular disease.
C-Reactive Protein (CRP):
Normal Values:
Relevance:
Low risk….
Moderate risk….
Critical Values….
C-Reactive Protein (CRP):
Normal Values: <3.0 mg/L.
Relevance:
Low risk: <1.0 mg/L.
Moderate risk: 1.0–3.0 mg/L.
High risk: >3.0 mg/L for cardiovascular events.
Critical Values: High-sensitivity CRP (hs-CRP) >10 mg/L indicates acute inflammation.
Serum Lipids:
Normal Values:
Total Cholesterol: ____ mg/dL.
LDL (Bad Cholesterol): ____ mg/dL.
HDL (Good Cholesterol): ____mg/dL.
Triglycerides: ____ mg/dL.
Relevance….
Critical Values: LDL _____/dL or total cholestrol ____ mg/dL is high risk for coronary artery disease.
Normal Values:
Total Cholesterol: <200 mg/dL.
LDL (Bad Cholesterol): <100 mg/dL.
HDL (Good Cholesterol): >60 mg/dL.
Triglycerides: <150 mg/dL.
Relevance: Elevated LDL or low HDL increases cardiovascular risk.
Critical Values: LDL >190 mg/dL or total cholesterol >240 mg/dL is high risk for coronary artery disease.
Electrolytes:
Normal Values:
Sodium (Na+)……
Potassium (K+)…
Calcium (Ca2+)…..
Magnesium (Mg2+)….
Relevance: Imbalances can cause arrhythmias and impact heart contractility.
Critical Values….
Electrolytes:
Normal Values:
Sodium (Na+): 135–145 mmol/L.
Potassium (K+): 3.5–5.0 mmol/L.
Calcium (Ca2+): 8.5–10.2 mg/dL.
Magnesium (Mg2+): 1.7–2.2 mg/dL.
Cardiac Enzymes
cTnT; cTnl (Troponin)
Onset, Peak, Duration
4 - 6
18 - 24
Up to 10 days
Cardiac Enzymes
CKMB
Onset, Peak, Duration
4 - 12
18 - 24
36 - 48
Cardiac Enzymes
LDH
Onset, Peak, Duration
6 - 12
24 - 48
6 - 8 days
Cardiac Enzymes
Myoglobin
Onset, Peak, Duration
1 - 2 hrs
8 - 10 hrs
24 hrs
BNP
VALUES
<100
100 - 300
>300
>600
>900
<100: No heart failure
100 - 300: Suggests possible
> 300: Mild HF
> 600: Mod HF
> 900: Severe HF
____ is secreted from the heart when stretched.
BNP
Elevations > 300 mild HF
>600 Mod HF
>900 Severe HF
Difference between 12 & 18 lead ELE cardio testing
18 can detect problems with Right Ventricular & Posterior Myocardial Infarction
Leads are placed on Chest, Arms, Legs
12 / 18 leads can diagnosis… (5)
Key data provided… (5)
Describe basically what it is and used for…
Diagnoses arrhythmias, ischemia, myocardial infarction, electrolyte imbalances, and structural abnormalities.
Data:
Heart rate, rhythm, axis, conduction delays, and ischemic changes (e.g., ST-segment elevation).
medical test that measures the electrical activity of the heart and is a key tool in diagnosing cardiovascular conditions:
Ambulatory ECG (Holter Monitor or Event Recorder) - Difference between them…
Type of data it records…
Holter Monitor: Portable device worn for 24–48 hours - Continuous monitoring
Event Recorder: Weeks - Records only during symptoms- Manuel & Automatic
Data:
Detects intermittent arrhythmias, monitors heart rate variability, and evaluates symptoms like palpitations or dizziness.
Exercise/ Drug induced Stress Test (dobutamine).
Purpose:
Identifies…(4)
Ischemia (Reduced Blood Flow) or
Coronary artery disease that may not be evident at rest.
Advantage: Detects exercise-induced changes such as ST-segment depression or arrhythmias.
Electrophysiologic Study (EPS)
Description….
Purpose:
Diagnoses arrhythmias and identifies their origins.
Evaluates conduction pathways and determines the effectiveness of treatments like ablation.
Procedure…
Invasive procedure uses catheters inserted into blood vessels and guided to the heart to record electrical activity from within.
Procedure
Electrical impulses are delivered to provoke arrhythmias under controlled conditions, allowing mapping of abnormal pathways.
Resting ECG/EKG
Purpose….
Prep:
Procedure….
Post-Procedure Care:
Purpose:
Detects arrhythmias, myocardial infarction, ischemia, and structural heart issues.
Provides a baseline heart electrical activity
Prep:
No specific preparation required.
Avoid heavy meals, caffeine, and smoking before the test to reduce interference.
Wear loose, comfortable clothing.
Procedure:
Electrodes are placed on the chest, arms, and legs.
Patient lies still while the ECG machine records heart activity for a few minutes.
Post procedure
No recovery needed; the test is non-invasive.
Resume normal activities immediately.
Exercise Stress Test
Purpose:
Prep:
Procedure:
Post-Procedure Care:
Purpose:
Evaluates heart function under stress (exercise).
Detects ischemia, arrhythmias, or exercise intolerance.
Prep:
Avoid caffeine, smoking, and heavy meals 2–4 hours before the test.
Wear comfortable exercise clothing and shoes.
Inform the provider of any medications being taken.
Procedure:
Patient walks on a treadmill or pedals a stationary bike with increasing intensity.
ECG, blood pressure, and symptoms are monitored.
Post-Procedure Care:
Rest and rehydrate after the test.
Report any persistent chest pain, dizziness, or discomfort.
Chemical Stress Test
Purpose:
Prep:
Procedure:
Post-Procedure Care:
(Meds withheld?)
Chemical Stress Test
Purpose:
Simulates the effects of exercise on the heart using medication (e.g., dobutamine, adenosine).
Used for patients unable to exercise.
Procedure:
Medication is administered intravenously to stress the heart.
ECG, blood pressure, and symptoms are monitored during the test.
Post-Procedure Care:
Rest after the test.
Monitor for any lingering side effects like headache, nausea, or palpitations.
Prep:
Avoid caffeine, smoking, and heavy meals for at least 4 hours before the test.
Certain medications (like beta-blockers) may need to be withheld—consult your provider.
Ambulatory ECG (Holter Monitor)
Purpose:
Prep:
Procedure:
Post-Procedure Care:
Ambulatory ECG (Holter Monitor)
Purpose:
Monitors heart rhythm continuously for 24–48 hours to detect intermittent arrhythmias or evaluate symptoms like palpitations.
Prep:
Shower before the appointment (as the monitor cannot get wet).
Avoid using lotions or oils on the skin.
Procedure:
Electrodes are attached to the chest and connected to a small recording device worn on the body.
Patient resumes normal daily activities while recording symptoms and activities in a diary.
Post-Procedure Care:
Return the monitor to the healthcare provider for analysis.
Follow up with results and next steps as advised.
Electrophysiologic Study (EPS)
Purpose:
Prep:
Procedure:
Post-Procedure Care:
Description: A catheter is sent to your heart and a Dr. triggers electric induced arythmias to: Determine cause of Arythmias, Determine Trouble with Electrical Pathway, & need for ablation (Creating Scars in the heart to prevent abnormal Arrhythmia)
Purpose:
Diagnoses arrhythmias, evaluates conduction pathways, and determines the need for treatments like ablation or pacemaker implantation.
Prep:
Avoid food and drink for 6–8 hours before the test.
Inform the provider about medications and stop certain drugs as directed.
Arrange for someone to drive you home post-procedure.
Procedure:
Catheters are inserted through veins (e.g., femoral vein) and guided to the heart.
Electrical impulses are delivered to provoke arrhythmias for mapping.
Procedure is performed under local anesthesia and conscience sedation.
Post-Procedure Care:
Monitor puncture site for bleeding or swelling.
Avoid strenuous activity for 24–48 hours.
Report any severe pain, swelling, or fever to the provider.