Heart Failure PP Flashcards

1
Q

1 cause of heart failure…

A

Systemic HTN

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2
Q

Causes of HF

A

Systemic HTN
MI
Valve disease
Diabetes

Others
Dysrhythmias
Obesity, Lung Disease, Sleep disorder (breathing)
CKD
Anemia, Hyperthyroidism, Infection, Drugs

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3
Q

The Frank-Starling Mechanism

Heart adjusts its force of contraction based on the amount of blood filling the ventricles (preload).

Maybe impaired by these problems (2)

A

Dilated cardiomyopathy or severe heart failure, where excessive stretch weakens the heart’s ability to pump effectively.

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4
Q

Increased preload & Cardiac output Leads to increased HR & BP / Increased Cardiac workload

Leads to…

A

LV dysfunction

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5
Q

Management of HF

MEDS

A

ACE inhibitors
ARBs
beta-blockers
aldosterone antagonists

interventions like device therapy or surgery, aim to slow or reverse these changes.

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6
Q

Description: Enlargement of the ventricular chambers due to increased volume or pressure.

Causes: Chronic volume overload (e.g., valve regurgitation) or heart failure.
Effects:

Initially helps maintain cardiac output.

Over time, leads to reduced contractility and heart failure.

A

Ventricular Dilation

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7
Q

Description: Thickening of the heart muscle (myocardium) in response to increased workload.

Types:
Concentric Hypertrophy: Due to pressure overload (e.g., hypertension).
Eccentric Hypertrophy: Due to volume overload (e.g., valve regurgitation).

Effects:
Can initially improve heart function.

May lead to stiff ventricles, diastolic dysfunction, and increased oxygen demand

A

Muscular Hypertrophy

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8
Q

Signs of HF (4)

A

Ventricular dilation
Muscle Hypertrophy
Apoptosis
Fibrosis

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9
Q

Ischemic heart disease (e.g., myocardial infarction).

Chronic hypertension leading to left ventricular hypertrophy.

Dilated cardiomyopathy.

Valvular diseases (e.g., aortic stenosis).
Arrhythmias.

Causes Low output or High output HF

A

Low output

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10
Q

Ischemic heart disease (e.g., myocardial infarction).

Chronic hypertension leading to left ventricular hypertrophy.

Dilated cardiomyopathy.

Valvular diseases (e.g., aortic stenosis).
Arrhythmias.

Leads to Low or High Output HF

A

Low output HF

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11
Q

Symptoms

Fatigue, weakness.

Cool extremities (due to poor perfusion).

Pulmonary congestion (e.g., dyspnea, orthopnea).

Peripheral edema.

Low or High Output HF

A

Low output HF

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12
Q

Causes:

Severe anemia.

Thyrotoxicosis (hyperthyroidism).

Arteriovenous fistulas or malformations.

Paget’s disease of bone.

Beriberi (thiamine deficiency).

Sepsis (due to profound vasodilation).

Low or high output HF

A

High

The heart pumps an abnormally high volume of blood, but it still fails to meet the metabolic demands of the body due to an underlying systemic condition.

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13
Q

Warm extremities (due to increased blood flow).

Bounding pulses.

Pulmonary congestion and edema (in advanced stages).

Tachycardia and palpitations.

Low or High Output HF

A

High

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14
Q

HF can be acute or chronic

Describe (4) from each…

A

Acute:
MI
Virus
Drugs
Dysrhythmias

Chronic:

HTN
Valve Diseases
DM
Lng Trm Edema

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15
Q

Primary cause of left sided HF

A

Primary Cause: Left ventricle dysfunction (commonly due to hypertension, ischemic heart disease, or valvular disorders).

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16
Q

Symptoms of Left sided heart failure (4)

A

Dyspnea (shortness of breath), especially on exertion or when lying down (orthopnea).

Paroxysmal nocturnal dyspnea (PND).

Fatigue and weakness due to reduced cardiac output
.
Pulmonary congestion causing cough, crackles, and frothy sputum.

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17
Q

Pathophysiology: Blood backs up into the lungs due to poor left ventricular pumping, leading to pulmonary edema

A

Left sided HF

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18
Q

Complications: Pulmonary hypertension, hypoxia, and possible progression to right heart failure.

Problem…

A

Left sided HF

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19
Q

Primary Cause: Right ventricle dysfunction (often secondary to left heart failure, chronic lung diseases, or pulmonary hypertension

A

Right sided HF

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20
Q

Symptoms of Right sided HF (4)

A

Peripheral edema (swelling in legs and feet).

Ascites (abdominal swelling).

Jugular venous distention (JVD).

Hepatosplenomegaly (enlargement of the liver and spleen).

Fatigue due to impaired venous return and decreased cardiac output.

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21
Q

Pathophysiology: Blood backs up into the systemic circulation due to poor right ventricular pumping, leading to venous congestion.

A

Right sided HF

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22
Q

Fluid Congestion:

____ heart failure → Pulmonary congestion.

_____ heart failure → Systemic venous congestion.

Symptoms Location:

____ → Respiratory-focused symptoms (lungs).

____→ Peripheral and abdominal symptoms.

A

Fluid Congestion:
Left heart failure → Pulmonary congestion.
Right heart failure → Systemic venous congestion.
Symptoms Location:
Left → Respiratory-focused symptoms (lungs).
Right → Peripheral and abdominal symptoms.

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23
Q

Cough worse at night
Dyspnea
Crackles or wheezes
Pleural effusion
Pink, forthy sputum
Tachypnea
S3 S4

Which HF

A

Left

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24
Q

Cardiac output with Left sided HF

A

Decrease

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25
Pulmonary congestion Which HF
Left
26
Pulse with left HF
Thready weak
27
JVD Enlarge liver & spleen Anorexia Nausea Dependent edema Swollen hands or feet Polyuria at night Weight gain Increased or decreased BP
Right HF
28
Systemic congestion Which HF
Right
29
Cor pulmonale is...
Specific type of right sided HF Always caused by pulmonary vascular condition (e.g., COPD, pulmonary embolism).
30
Most important lab test for determining HF Values
BNP <100 Normal 100 - 300 further investigation 300 mild HF 600 mod HF 900 severe HF
31
Name Diagnostic for HF...
H&P ECG 2D echo (EF, Ab values, wall changes) CXR
32
Describe New York Association Functional Classification (For HF) Class 1 - 4
1: No symptoms with ordinary activity Class II Description: Slight limitation of physical activity. Symptoms: Comfortable at rest, but ordinary physical activity (e.g., walking up stairs, moderate exertion) results in fatigue, palpitation, dyspnea, or angina. Functional Status: Mild symptoms with normal daily activities. Class III Description: Marked limitation of physical activity. Symptoms: Comfortable at rest, but less than ordinary activity (e.g., light housework, short walking) causes fatigue, palpitation, dyspnea, or angina. Functional Status: Significant symptoms even with minimal exertion. Class IV Description: Inability to carry on any physical activity without discomfort. Symptoms: Symptoms of heart failure (e.g., fatigue, dyspnea, angina) are present at rest. Any physical activity increases discomfort. Functional Status: Severe limitation; often bedridden or unable to perform daily tasks.
33
Description: No limitation of physical activity. Symptoms: Ordinary physical activity does not cause fatigue, palpitation, dyspnea (shortness of breath), or angina. Functional Status: Asymptomatic during normal activities.
Class 1
34
Description: Slight limitation of physical activity. Symptoms: Comfortable at rest, but ordinary physical activity (e.g., walking up stairs, moderate exertion) results in fatigue, palpitation, dyspnea, or angina. Functional Status: Mild symptoms with normal daily activities.
Class II
35
Description: Marked limitation of physical activity. Symptoms: Comfortable at rest, but less than ordinary activity (e.g., light housework, short walking) causes fatigue, palpitation, dyspnea, or angina. Functional Status: Significant symptoms even with minimal exertion.
Class III
36
Description: Inability to carry on any physical activity without discomfort. Symptoms: Symptoms of heart failure (e.g., fatigue, dyspnea, angina) are present at rest. Any physical activity increases discomfort. Functional Status: Severe limitation; often bedridden or unable to perform daily tasks.
Class IV
37
Nitroglycerin has this affect on preload & afterload
Lowers
38
Pregnant women have this type of precaution with cardiologist...
Go to a specialist
39
Why consider use of ARBS instead of ACE Inhibitors...
Less serious SE (Dry Cough & Angioedema)
40
ARNI (Angiotensin Receptor-Neprilysin Inhibitor) refers to a class of medications used to treat....
HF with reduced ejection fraction (HFrEF). The most commonly used ARNI is sacubitril/valsartan
41
ARNI Is a combination of Sacubitril (neprilysin inhibitor) & Valsartan (angiotensin receptor blocker - ARB) The combination results in reduced stress on the heart and improved cardiac function. Approved for what problem...
Approved for HFrEF (Heart Failure with Reduced Ejection Fraction) to reduce the risk of cardiovascular death and hospitalization for heart failure.
42
SE For ARNI (6)
Hypotension. Hyperkalemia. Dizziness. Angioedema (rare but serious). Renal impairment. Cough (less common than with ACE inhibitors). Basically the same as ACE & ARBS
43
When to hold K sparing Diuretucs Uses Heart failure (e.g., spironolactone in HFrEF). Hypertension (as an adjunct to other diuretics). Edema associated with liver cirrhosis or nephrotic syndrome. Hyperaldosteronism (primary or secondary). When to hold..
K >5 Creatinine >2.5
44
Adult males 0.7–1.3 mg/dL (62–115 µmol/L) Adult females 0.6–1.1 mg/dL (53–97 µmol/L) Creatinine levels norms What do highs and lows means
High Dehydration CKD MEDS: ACE / ARBS NSAIDS HF High protein diet Rhabdomyolysis Low Liver problem Preggers Low muscle mass
45
Diuretics help with remodeling of the heart T or F
T
46
Best medications to reduce afterload (3)
ACE ARB ARNI Angiotensin Receptor-Neprilysin Inhibitor
47
Slide SE For ACE (4)
Low BP Worsening Kidney Function Hyperkalemia Chronic Cough Angioedema
48
How long to be off an ACE befire starting an ARI
72 hrs
49
Contradictions to ARNI (4)
Concurrent Use of ACE / ARB DM Preggers
50
Valsartan / Sacubitril Is this type of medication... Cost 12$ per day
ARNI Angiotensin Receptor-Neprilysin Inhibitor
51
Reduce preload (3)
Diet Diuretics Venous Vasodilators
52
Traditional HF Diet 1. Limit sodium to.... 2. Fluid restrictions (class IV patients) 3. Weight self (How Often) 4. Weight gain of ___ in 1 day or ____ in 1 week = contact HCP
1. 2 G 2. 2 L/day 3. Daily weight 4. 3# in 1 day or 5# in 1 week
53
Therapeutic level of Digoxin
0.5 - 2 ng/ml
54
Medication Antidote for Digoxin... Amount....
Digi fab 0.125
55
Last Resort for HF
Left Ventricular Assist Device (LVAD)
56
Beta-Blockers have 3 effects Adrenergic .... Primary Cholinergic.... Glycopenic ....
Adrenergic - Decreased heart rate and contractility. - Bronchoconstriction (non-selective). - Vasoconstriction (in certain vascular beds). Cholinergic - Increased parasympathetic (vagal) tone. - Bradycardia and AV node conduction delay. Glycopenic - Impaired glycogenolysis and glucose release. - Masked symptoms of hypoglycemia in diabetics.
57
Sweating Shakiness or tremors Tachycardia (rapid heartbeat) Anxiety or nervousness Irritability or mood swings Palpitations Hunger Neuroglycopenic Symptoms (due to insufficient glucose to the brain): Confusion or disorientation Difficulty concentrating Slurred speech Dizziness or lightheadedness Weakness or fatigue Blurred vision Headache Loss of coordination Seizures (in severe cases) Loss of consciousness or coma (severe hypoglycemia) Other Symptoms: Nausea Cold, clammy skin Hypo or hyperglycemia
Hypoglycemia Think drunk with Tachycardia
58
Why are BB not a good first choice in black men.
They will refuse to take them due to ED
59
Diuretics alone can be given to treat HF
F Never alone
60
Types of meds given to treat HF
1.ACE Inhibitors Examples: Enalapril, Lisinopril, Ramipril 2. Angiotensin Receptor Blockers (ARBs) Examples: Losartan, Valsartan, Candesartan 3. Angiotensin Receptor-Neprilysin Inhibitors (ARNIs) Example: Sacubitril/Valsartan (Entresto) 4. Beta-Blockers Examples: Carvedilol, Metoprolol succinate, Bisoprolol 5. Mineralocorticoid Receptor Antagonists (MRAs) Examples: Spironolactone, Eplerenone 5. Diuretics Examples: Furosemide, Bumetanide, Torsemide Ivabradine 6. Hydralazine and Nitrates (Combination Therapy) Example: Hydralazine/Isosorbide dinitrate (BiDil) SGLT2 Inhibitors Examples: Dapagliflozin, Empagliflozin
61
Aldosterone antagonists aka potassium sparring diuretics Give examples... Hold...
Spironolactone Eplerenone Hold K>5 Creatinine >2.5
62
SE of spironolactone (3)
Hyperkalemia Gynecomastia Impotence
63
Venodilators Dilate veins to decrease blood returning to the heart Tolerance can develop Examples....
Nitroglycerin (Store in Dark colored Glass container) Isosorbide
64
Neseritide (natrecor) Type of med... Action: Causes loss of NA in renal tubules and vasodilation. Used for....
Type : BNP Type venodilator Used for Acute severe HF
65
Digitalis / Digoxin Action... Describe in general..... Reduces HF symptoms Increaes exercise tolerance Improve hemodynamics Decrease progression of HF Improves rate of survival....?
Improves force of heart contractions while decreasing HR DOESN'T IMPROVE SURVIVAL RATE
66
SE of Digoxin OD >2ng /ml
Anorexia/ Nausea Mental Status change Halo around lights Arrhythmia
67
IV inotropes Exp. Milrinone (Primacor) Dobutamine (Dobutrex) Dopamine Used for... Action...
Acute CHF Increase contractility and dilation peripheral vessels
68
New order for IV furosemide & Digoxin Which lab result is most important to look at.... Why...
K Hypokalemia increase risk of Digoxin toxicity
69
Intra-aortic balloon pump Used.... Action....
Used acute MI/HF to decrease cardiac workload Increases cardiac output and increases O2 delivery to myocardium
70
Impella is.... Describe...
LVAD Pumps blood for LV to aorta 2.5 - 5 L/M Short term upto 10 days but patients often need it longer
71
SE of BB
Hypotension Bradycardia Fluid Retention Fatigue Impotence Mask hypoglycemia in Diabetics
72
PT goal for Congestive HF when ready...
200 - 400 ft walk
73
Evaluation of LVS function...
Echo or Cath
74
Prescribed at discharge fir LVSD left ventricle systolic dysfunction
ACE / ARB BB Smoking cessation
75
Most common cause of Mitral Stenosis
Rheumatic fever
76
Describe affects of Mitral Stenosis
Pulmonary congestion Right sided HF Preload decrease CO Falls
77
Stenosis restricts blood flow through the valve due to narrowing, while regurgitation causes blood to flow backward due to improper valve closure. Stenosis leads to increased pressure before the valve (in the chamber receiving blood), whereas regurgitation increases volume in the chamber behind the valve. T or F
T
78
Chordae tendinae contract & shorten Valve leaflets... LA - LV Blood flow impaired LA dilates, PAP increases, RV hypertrophic & CO DECREASES This problem....
Fuse & become stiff Mitral stenosis
79
Calcification/ muscle weakness prevent valve closure. Blood flows back to LA during systole Decreased CO LA dilation Pulmonary Congestion RV failure This problem...
Mitral regurgitation
80
Pulmonary congestion AFIB R HF Anxiety Atypical chest pain Murmur S3 S/S For..m
Mitral regurgitation
81
Valve leaflets enlarge and prolapse into LA during systole This problem...
Mitral valve prolapse
82
Aortic stenosis Starts when the aorta closes and blood backs up all the way to the Pulmonary Artery. Happens during Systole Leads to this type of HF....
Left sided
83
Aortic stenosis Backflow of blood from Aorta to ventricles during diastole LV dilates then hypertrophies This outcome...
LV failure
84
Diagnostic testing for valvular disease ...
X ray Echocardiography Exercise tolerance test Cardiac Catheterization ECG
85
Prosthetic valve Mech: _____ Bio _____ IRN #
Mechanical 2.5 - 3.5 Bio 2 - 3
86
TAVR Define...
TAVR is a minimally invasive surgical procedure used to treat severe aortic stenosis (narrowing of the aortic valve) Especially in patients who are not candidates for traditional open-heart surgery.
87
New aortic valve is implanted through a catheter, typically inserted via the femoral artery (in the groin) or sometimes through other arteries or the chest. The catheter delivers the new valve, which is expanded within the existing, narrowed valve to replace it. Name of procedure... Who its for...
TAVR Transcatheter aortic valve replacement Patients with severe aortic stenosis who are at high risk for complications from traditional valve surgery
88
Endocardial injury - vegative lesions - valve destruction SS Recurrent fever Micro emboli Petechiae Splinter Hemorrhage Organ Infarction Diagnostic Murmur Echo Blood culture Name problem...
Endocarditis
89
Endocarditis Endocardial injury - Vegative lesions - valve destruction SS Recurrent fever Micro emboli Petechiae Splinter Hemorrhage Organ Infarction Diagnostic Murmur Echo Blood culture Treatment....
Antibiotics
90
Inflammation of the pericardial layers of heart. SS Pericardial Rub / pain Fever Cardiac Tamponade Causes: Infection Cancer Cardiac Surgery Connective tissue disease Name problem and treatment....
Pericarditis Colchicine: Reduces symptoms and recurrence. Steroids Antibiotics NSAIDS
91
Pt has Pericarditis SS Pericardial Rub / pain Fever Cardiac Tamponade Pt was given Colchiche Steroid Antibiotics What is the treatment for Cardiac Tamponade....
Pericardiocentesis. Needle drains fluid from around the heart
92
Rheumatic Carditis is Inflammation of all layers of the heart SS Heart murmurs (due to valve inflammation and damage). Tachycardia Signs of heart failure (dyspnea, fatigue, peripheral edema). Systemic: Fever Joint pain and swelling (migratory polyarthritis) Skin manifestations (erythema marginatum, subcutaneous nodules) Chorea (involuntary, jerky movements) Treatment....
Antibiotics min 10 days
93
Rheumatic Carditis is Inflammation of... Give antibiotics min 10 days Diagnostic...
All heart layers Echocardiogram Lab Elevated CRP
94
Fluid accumulation in pericardium Sudden decrease in cardiac output Name problem... Solution....
Cardiac Tamponade Solution: Pericardiocentesis
95
Muscles fibers of heart are damaged causing them to be Hard, Thick, Rigid. Causes: Etoh, infection, inflammation, poor nutrient, drugs, genetic, Unknown Name problem...
Cardiomyopathy
96
Types of Cardiomyopathy Dilated ____ wall thickness, _____ ventricle
Normal wall thickness, enlarged ventricle
97
Types of Cardiomyopathy Hypertrophic ______, ________ muscle walls, _____ filling
Thick and stiff muscle walls, impaired filling
98
Types of Cardiomyopathy Restrictive - rarest _____ tissue replaces muscle tissue
Scar tissue replaces regular muscle tissue
99
Types of Cardiomyopathy Arrhythmogenic Right Ventricular ______ & _______ tissue replaces muscle
Fatty & Fibrous tissue replaces muscle
100
Manifestions of Cardiomyopathy include (4)
Dyspnea Fatigue Palpation Dysrhythmias
101
Hypertropic Cardiomyopathy can have chest pain at rest unrelieved by Nitroglycerin. What can be the outcome...
Sudden Death
102
Cardiomyopathy Dilated & Restrictive Treatment...
Same as HF Medications: ACE inhibitors/ARBs: Reduce afterload and prevent heart remodeling. Beta-blockers: Decrease heart rate and improve ventricular function. Diuretics: Relieve fluid overload (edema, pulmonary congestion). Aldosterone antagonists: (e.g., spironolactone) to manage fluid retention and reduce cardiac fibrosis. Anticoagulants: Prevent thromboembolism if atrial fibrillation or reduced ejection fraction is present Digoxin: Improves contractility in select cases. Devices/Interventions: Implantable Cardioverter-Defibrillator (ICD): Prevent sudden cardiac death in those with a high risk of arrhythmias. Cardiac Resynchronization Therapy (CRT): For patients with dyssynchronous ventricular contraction. Heart transplantation: For refractory cases.
103
Cardiomyopathy Obstructive Treatment....
BB CCB Activity Restrictions
104
Cardiomyopathy Arrhythmogenic Treatment...
Unclear BB CCB Ablation ICD
105
Ivabradine is a heart rate-lowering medication used primarily to manage specific types of heart failure and angina. Used for... Used in patients..
Increasing EF EF <35 Used in patients Are in sinus rhythm. Have a resting heart rate ≥70 beats per minute. Are already on maximally tolerated beta-blockers or have a contraindication to beta-blockers.
106
Heart stretches & doesn't come back describes in general this heart condition...
Cardiomyopathy
107
Prosthetic valve IRN values Mech.... Biological....
Mechanical 2.5 - 3.5 Biological 2 - 3