Test 2 CAD Flashcards
Insufficient oxygen supply to the myocardium….
Ischemia
Necrosis when ischemia is prolonged and decreased perfusion causes irreversible damage to tissue….
Infarction
Difference in Stable & Unstable angina in regards to what is clogging the artery…
Stable Angina: Fixed atherosclerotic plaque
Unstable Angina: Plaque & Platelets
Describe difference in the artery clog with:
Non ST elevation MI
ST elevation MI
Non ST elevation MI: Plaque, Platelets, Thrombus blocks vessel part way
ST elevation MI: Plaque, Platelets, Thrombus blocks vessel fully
Formation of Plaque within artery wall
Possibly due to injury
Causes;
Mechanical
Chemical
Physiological
Impaired Na-K pump
Diabetes
Inflammation
Atherosclerosis
Cholesterol is needed for body functioning
20 - 40% comes from food.
Where does the rest come from…
Produced by the liver
HDL
Optimal
Desirable
Undesirable
Optimal >60
Desirable >40
Undesirable <40
Triglycerides
Low
Borderline
High
Very high
Low: <150
Borderline 150 - 199
High 200 - 499
Very high >500
Total cholesterol
Desirable
Borderline
High
Desirable <200
Borderline 200 - 239
High >240
LDL
Optimal
Near Optimal
Borderline
High
Very high
Optimal <100
Near Optimal 100 - 129
Borderline 130 - 159
High 160 - 189
Very high >190
Define:
Moves cholesterol away from the arterial wall
Carries cholesterol to the arterial wall
Transfers triglycerides to cells
High density lipoprotein cholesterol
HDL
Moves cholesterol away from the arterial wall
Low Density lipoprotein cholesterol
LDL
Carries cholesterol to the arterial wall
Very low-density lipoprotein
VLDL
Transfers triglycerides to cells
______ is a chronic disease where plaque builds up inside arteries, leading to narrowing and reduced blood flow. It is a leading cause of cardiovascular diseases like coronary artery disease (CAD), stroke, and peripheral artery disease (PAD).
Atherosclerosis
Atherosclerosis is a chronic disease where plaque builds up inside arteries, leading to narrowing and reduced blood flow. It is a leading cause of cardiovascular diseases including (3)
Coronary artery disease (CAD)
Stroke,
Peripheral artery disease (PAD).
Fatty steak develops in between layers of the artery wall.
_____ engulf the deposited cholesterol & convert to Giant Foam Cells
Formation of Fibrous cap over lipid core
QUESTION….
- This plaque can rupture & a thrombus forms at the site causes blockage of oxygen & death to heart muscles THIS IS CALLED…
- The plaque stays stable and continues to thicken. This disease process…
Macrophages
- Acute coronary syndrome
- Stenosis
Causes of atherosclerosis (5)
Endothelial Damage: Injury to the artery lining due to factors like:
High blood pressure
High cholesterol
Smoking
Diabetes
Lipid Accumulation: LDL (low-density lipoprotein) cholesterol enters the damaged wall and oxidizes.
Inflammation: White blood cells (macrophages) engulf oxidized LDL, forming foam cells.
Plaque Formation: Foam cells accumulate, leading to fatty streaks and plaque formation.
Narrowing of Arteries: Plaques can calcify, harden, or rupture, causing blood clots.
DASH stands for
Dietary Approach to Stop Hypertension
____ juice can prevent & reverse atherosclerosis
Pomegranate
Teachings for: HMG coA Reductase Inhibitors (Statins)
Teachings (3)
Take in evening (When cholesterol synthesis occurs)
Avoid Grapefruit Juice (Increases SE)
Monitor CK levels (Statins can cause muscle damage)
How do statins work…
They inhibit the enzyme HMG in the liver which stops the production of cholesterol. They also remove LDL fron the blood
What does Pleiotropic effects of Statins mean….
Addition good effects the medication causes.
Anti-inflammatory and plaque-stabilizing properties, further contribute to cardiovascular protection.
Low cholesterol levels will have these problems…
Increased risk of viral infection & cancer
Hormonal
Neurological
Vitamin deficiency
Gemfibrozil
Fenofibrate
Examples of which type of medication…
With what effects…
Used alone?
Fibric Acid Derivatives
Reduces LDL, VLDL, & Triglycerides. INCREASE HDL levels
Appears beneficial on insulin resistance
Used alone or with Statins
Fibric Acid Derivatives
(Fenofibrate & gemfibrozil)
Lower all bad cholesterol & raise good
Benefical on insulin resistance
Used alone or in conjunction with Statins
Name
SE & TEACHINGS…
Muscle pain or weakness (myalgia)
Headache
Nausea or upset stomach
Diarrhea or constipation
Fatigue
Mild elevations in liver enzymes
Serious
Myopathy: Severe muscle pain with elevated creatine kinase (CK).
Rhabdomyolysis: Rare but life-threatening condition causing severe muscle breakdown, leading to kidney damage.
Liver toxicity: Significant liver enzyme elevation or hepatitis.
Teaching:
Avoid ETOH can cause elevated liver enzymes
Nicotinic Acid (Niacin)
Action….
SE….
High doses will lower VLDL & Raise HDL
SE:
FLUSHING & Itching
Increased Uric Acid
Increased BS