Weak Chemical Interaction: The Heart of Molecular Genetics Flashcards

1
Q

Covalent bonds

A
  • peptide
  • glycosidic
  • phosphodiester
  • very strong
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

weak bonds

A
  • non-covalent bonds
  • easily broken and reformed to allow a specific interaction between and within biological macromolecules (DNA, RNA, and proteins) to be formed and readily changed
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

major types of weak chemical interactions

A
  1. Van der Waals forces
  2. Hydrogen bonds
  3. Ionic bonds
  4. Hydrophobic interactions
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Strength of interactions

A
  • Covalent > Ionic > Hydrogen > Hydrophobic

- bond energies for weak bonds much lower than for non covalent bonds and can easily be made and broken.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Combined versus Uncombined

A
  • ratio between combined and uncombined molecules
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

if ratio is high

A
  • strong bond

- combined

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

if ratio low

A
  • weak bond

- uncombined

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Higher Delta G

A
  • more reactants in combined form rather than uncombined form.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

small difference in bond energy

A
  • BIG difference in ratio of combined and uncombined components.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

A good fit is necessary

A
  • a large # of simultaneous interactions

- dependent on distance and angles of interaction (geometry)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

The Law of Mass Action Applies

A
  • amount of combined vs uncombined dependent upon total concentration
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

if low concentration

A

more likely to be uncombined

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

if high concentration

A

will be more likely to interact with each other - combined

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

hydrophobic interactions

A
  • Van der Waals forces, hydrogen bonds, and ionic bonds are responsible for RECOGNITION AND SPECIFICITY.
  • But the DRIVING FORCE (the most important consideration in the overall STRENGTH of interaction between two macromolecules) is the HYDROPHOBIC INTERACTION
How well did you know this?
1
Not at all
2
3
4
5
Perfectly