Repetitive DNA Part 3 Flashcards
1
Q
multiple copy histone genes
A
- some may all be transcribed in the same direction
- some may not
- different strands may serve as coding strand depending on if the genes arrows point in different directions
2
Q
repeat expansion mutations
A
- due to problems during replication
- diseases caused by CAG repeats due to Gln
- most people have a low number of Gln repeats near important genes
3
Q
hairpin-induced trinucleotide repeat instability
A
- nascent-strand hairpin formation
- template-strand hairpin formation
4
Q
nascent-strand hairpin formation
A
- hairpin formed after first replication on the newly synthesized DNA
- DNA is now expanded and passed on afterwards
5
Q
template-strand hairpin formation
A
- hairpin formed after first replication on template DNA
- DNA is now contracted and passed on afterwards
6
Q
examples of genetic diseases caused by expanding trinucleotide repeats
A
- fragile-X syndrome
- Huntington disease
- many cause problems with nervous system and/or coordination
7
Q
histone coding genes as examples of
A
- tandemly-repeated, protein-coding genes.
8
Q
genes that code for ribosomal RNAs as examples of
A
- tandemly repeated DNA (multiple-copy, RNA-coding genes).
9
Q
the arrangement of genes within repeated units
A
- varies from organism to organism.
