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HEME/LYMPH > WBC Disorders VI > Flashcards

WBC Disorders VI Flashcards

1
Q

maltomas

A

marginal zone lymphoma

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2
Q

extranodal marginal zone lymphomas

A

continuum between reactive hyperplasia and lymphoma

begin as polyclonal

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3
Q

sjogren

A

salivary - may lead to marginal zone lymphoma

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4
Q

hashimotos

A

thyroiditis - may lead to marginal one lymphoma

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5
Q

helicobacter

A

h. pyloric - chronic gastritis - may lead to marginal zone lymphoma

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6
Q

BRAF mutation

A

hairy cell mutation

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7
Q

prognosis of hairy cell

A

excellent

-gentle chemo - remission

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8
Q

atypical mycobacterial infections

A

hairy cell leukemia

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9
Q

hairy cell leukemia demo

A

middle age white male

55yo

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10
Q

dry tap

A

hairy cell leukemia

fibrosis of marrow

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11
Q

massive splenomegaly

A

hairy cell leukemia

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12
Q

massive splenomegaly, atypical mycobacterial infection, pancytopenia

A

hairy cell leukemia

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13
Q

far east

A

more common to have T cell/NK cell neoplasms

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14
Q

gene rearrangement in ALK on chromosome 2p23

A

anaplastic large cell lymphoma

also CD30

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15
Q

hallmark cells

A

anaplastic large cell lymphoma

large anaplastic cells with horseshoe nuclei and voluminous cytoplasm

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16
Q

cluster around venules and infiltrate lymphoid sinuses

A

anaplastic large cell lymphoma

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17
Q

peripheral T cell lymphoma, unspecified

A

lymphadenopathy, eosinophilia, pruritis, weight loss

not good prognosis

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18
Q

anaplastic large cell lymphoma prognosis

A

children with ALK - good

adults no ALK - bad

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19
Q

CD30+

A

anaplastic large cell lymphoma

and hodgkins

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20
Q

HTLV-1 infection

A

adult T cell leukemia/lymphoma

japan, w. africa, caribbean

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21
Q

adult T cell leukemia/lymphoma

A

demyelinating disease of CNS and spinal cord

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22
Q

clover leaf, flower cells

A

adult T cell leukemia/lymphoma

23
Q

adult T cell leukemia/lymphoma prognosis

A

rapidly progressive
-fatal

only skin - more indolent course

24
Q

tumor of CD4 helper T cells that homes to skin

A

mycosis fungoides

25
Q

3 stages of mycosis fungoides

A

pre-mycotic - inflammation
plaque
tumor

26
Q

cerebriform tumor cells

A

mycosis fungoides sezary cells

27
Q

exfoliative erythroderma

A

sezary syndrome

mycosis fungoides

28
Q

sezary syndrome

A

skin involvment of mycosis fungoides with exfoliative erythroderma

sezary cells - cerebriform nuclei

29
Q

STAT3 mutation

A

large granular lymphocytic leukemia

30
Q

large granular lymphocytic leukemia

A

NK/T cell

large lymphocytes - blue cytoplasm and azurophilic granules

neutropenia/anemia**

31
Q

felty syndrome

A

rheumatoid arthritis
splenomegaly
neutropenia

with large granular lymphocytic leukemia

32
Q

T cell LGLL

A

indolent

33
Q

NK cell LGLL

A

aggressive

34
Q

nasopharyngeal mass

A

extranodal NK/T cell lymphoma

large azurophilic granules

35
Q

extranodal NK/T cell lymphoma

A

EBV association

aggressive prognosis

36
Q

extranodal NK/ T cell lymphoma prognosis

A

no chem response

responds to radiation**

37
Q

hodgkins demo

A

32yo average age

  • young adults/adolescents
  • also older adults

curable - most cases

38
Q

reed sternberg cells

A

giant B cell - in hodgkins lymphoma

release cytokines, chemokines and other factors that induce accumulation of reactive lymphocytes, macros, and granulocytes

aneuploid

39
Q

hodgkins lymphoma

A

single node then spread in contiguous fashion

-can be staged

40
Q

epigenetic changes

A

reed sternberg cells in hodgkins

41
Q

owl eye nuclei

A

reed sternberg cells

42
Q

variants of RS cells

A

mononuclear

lacunar - folded nucleus, multilobated

lymphohistiocytic - polyploid nuclei

43
Q

types of hodgkins

A 
1 nodular sclerosis
2 mixed cellularity
3 lymphocyte rich
4 lymphocyte depletion
5 lymphocyte predominance

first 4 - CD15, CD3
5 - CD20
1, 5 - no EBV

44
Q

nodular sclerosis

A

type 1 hodgkins

  • good prognosis
  • CD15, CD30
  • no EBV
  • lower cervical, supraclavicular nodes
45
Q

mixed cellularity

A

type 2 hodgkins

  • EBV associated
  • CD15, CD30
  • males, night sweats, weight loss
  • good prognosis
46
Q

lymphocyte-rich

A

type 3 hodgkins

  • EBV associated
  • CD15, C30
  • excellent prognosis
47
Q

lymphocyte depletion

A

type 4 hodgkins

  • EBV associated
  • CD15, CD30
  • elderly, HIV, non-industrialized
  • worse prognosis than first 3
48
Q

lymphocyte predominance

A

type 5 hodgkins

  • no EBV association
  • CD20/BCL6
  • lymphohistiocytic cells
  • popcorn cells

may transform to DLBCL

49
Q

first 4 hodgkins types

A

classic**

50
Q

hodgkin vs. NHL

A

hodgkin - single group of nodes

  • orderly spread
  • extranodal presentation - rare
  • no waldeyer or mesenteric node involvement
51
Q

helminths

A

Th2

52
Q

intracellular pathogen

A

Th1

53
Q

extracellular pathogen/fungi

A

Th17

HEME/LYMPH (11 decks)

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