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HEME/LYMPH > WBC Disorders V > Flashcards

WBC Disorders V Flashcards

1
Q

BCL6 dysregulation

A

diffuse large B cell lymphoma

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2
Q

most common form of NHL in US

A

DLBCL

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3
Q

t(14;18)

A

DLBCL

same as follicular

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4
Q

EBV and KSHV/HHV-8

A

associated with DLBCL

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5
Q

EBV and DLBCL

A

severe T cell deficiency

with DLBCL

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6
Q

KSHV/HHV8

A

primary effusion in malignant pleural effusion

with DLBCL

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7
Q

DLBCL demo

A

adults 60yo

also children and young adults

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8
Q

DLBCL prognosis

A

aggressive
-rapidly fatal without tx

chemo - good prognosis

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9
Q

rapidly growing mass at waldeyers ring

A

DLBCL

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10
Q

two classes of DLBCL

A

BCL6 and BCL2 rearrangement

BCL2 - though to be morph of follicular lymphoma

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11
Q

starry sky pattern

A

burkitt lymphoma

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12
Q

categories of burkitt lymphoma

A

african endemic
sporadic non-endemic
HIV

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13
Q

C-myc oncogenes

A

burkitt lymphoma

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14
Q

translocation of C-myc on chromosome 8

A

ALL burkitt lymphomas

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15
Q

mandibular burkitt

A

african - endemic

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16
Q

GI burkitt

A

sporadic - non-endemic

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17
Q

aggressive burkitt

A

HIV

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18
Q

fastest growing human tumor

A

burkitt

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19
Q

EBV and burkitt

A

all endemic
25% HIV
15-20% sporadic

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20
Q

warburg effect

A

in burkitt

MYC oncogene

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21
Q

NO BCL2

22
Q

burkitt demo

A

adolescents or young adults with extranodal masses

23
Q

most common and deadly plasma cell dyscrasia

A

multiple myeloma

24
Q

t(8;14)

A

translocation involving MYC gene - burkitt lymphoma

25
Q

rouleaux formation

A

multiple myeloma

due to high M proteins

26
Q

path fractures, hypercalcemia, renal failure, immune abnormalities

A

multiple myeloma

27
Q

flame cells, mott cells, russel bodies (cyto inclusion), and dutcher bodies (nuclear inclusions)

A

multiple myeloma

28
Q

bence joines proteins

A

light chains in urine

toxic to renal tubular cells

can lead to myeloma kidney

29
Q

most common multiple myeloma

A

monoclonal IgG-kappa

30
Q

CD138, syndecan 1, CD56

A

multiple myeloma

31
Q

definitive diagnosis of multiple myeloma

A

bone marrow examination

32
Q

most common plasma cell dyscrasia

33
Q

dx of MM

A

> 3g/dL of monoclonal Igs in serum

34
Q

single mass in bone or soft tissue

A

solitary myeloma (plasmacytoma)

uncommon

35
Q

lack of sx and high plasma M component

A

smoldering myeloma

36
Q

multiple myeloma demo

A

men, african, 65-70yo

37
Q

most myelomas

A

> 3g serum Ig

and/or >6g bence jones proteinuria

38
Q

solitary plasmacytoma

A

solitary lesion

progress to MM 10-20 yrs

extraosseous - cure if resection
-often upper respiratory

39
Q

smoldering myeloma

A

asymptomatic with M protein >3g serum

prgress to MM 15 yrs

middle ground of MM and MGUS

40
Q

multiple myeloma prognosis

A

survival 4-7 yrs
untreated 6-12 months

cyclin D1 - good prognosis
deletion 13, 17, t(4;14) - bad prognosis

41
Q

confusion, lethargy, constipation, renal dysfunction, bacterial infections

A

multiple myeloma

CNS - from hypercalcemia

42
Q

monoclonal gammopathy of uncertain significance

A

asymptomatic and serum Ig < 3g/dL

early stage of multiple myeloma development

**should periodically assess patient for serum M component and bence-jones proteins in urine

43
Q

lymphoplasmacytic lymphoma

A

B cell neoplasm
60-70yo

fraction to plasma cells

secretes IgM - high levels
-lead to hyperviscosity - waldenstrom

44
Q

waldenstrom macroglobulinemia

A

hyperviscosity due to large IgM release

with lymphoplasmacytic lymphoma

45
Q

hyperviscosity leads to

A

visual impairment - venous congestion

neuro problems - HA, dizzy, deaf - sluggish blood flow

bleeding

cryoglobulinemia - precipitate at low T - raynauds, urticaria

46
Q

lymphoplasmacytic lymphoma prognosis

A

incurable

  • IgM alleviated with plasmapharesis
  • also temp tx is anti-CD20 Ab

survival 4 years

47
Q

overexpression of cyclin D1

A

mantle cell lymphoma

48
Q

t(11;14)

A

mantle cell lymphoma
-IgH on 14 and cyclin D on 11

overexpression of cyclin D1
-more G1 to S transition

fluorescence in situ hybridization

49
Q

painless lymphadenopathy, spleen and gut sx

A

mantle cell lymphoma

50
Q

mantle cell lymphoma prognosis

A

incurable - survival 3-4 yrs

organ dysfunction caused by tumor infiltration

HSC transplant - some promise

51
Q

lymphomatoid polyposis

A

mantle cell lymphoma

52
Q

cyclin D1, CD19, CD20, CD5, no CD23

A

mantle cell lymphoma

HEME/LYMPH (11 decks)

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