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HEME/LYMPH > Heme, Iron and Bilirubin Metabolism II > Flashcards

Heme, Iron and Bilirubin Metabolism II Flashcards

1
Q

positive coombs

A

ABO incompatability

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2
Q

increased indirect bilirubin

A

usually pre-hepatic

-hemolysis

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3
Q

increased direct bilirubin

A

post-hepatic

-obstruction

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4
Q

phototherapy

A

trans to cis bilirubin

-cis in your piss

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5
Q

kernicterus

A

neuro sx

-severe hyperbilirubinemia

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6
Q

free unconjugated bilirubin

A

can cross BBB - to kernicterus

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7
Q

pale stool

A

post-hepatic

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8
Q

gallstones

A

alcoholism

post-hepatic

abdominal radiograph or CT

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9
Q

sentinel loop

A

air filled LUQ of small intestine

seen on radiography for gallstones

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10
Q

mobilferrin

A

transport of Fe2+ in cytoplasm of cell - to basolateral membrane

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11
Q

hephaestin

A

ferroxidase

converts Fe2 to Fe3 for plasma carry - via transferrin

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12
Q

hepcidin

A

down regulates ferroportin

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13
Q

hemochromatosis

A

with loss of hepcidin

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14
Q

anemia of chronic disease

A

with increased hepcidin

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15
Q

UDPGT

A

converts unconjugated to conjugated bilirubin - in liver SER

adds glucuronide to the bilirubin

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16
Q

stercobilin

A

stool black pigment

17
Q

urinary bilirubin

A

if there is increased serum conjugated bilirubin

18
Q

intestinal bacteria

A

convert conjugated bilirubin to urobilinogen

that may be excreted or reabsorbed

19
Q

normal serum bilirubin

A

0.2-1

<0.2 - conjugated

20
Q

jaundice and icterus

A

elevated serum bilirubin

21
Q

prehepatic

A

hemolysis

unconjugated bilirubin

22
Q

gilberts

A

stressed college student gets jaundice

mutation - impaired hepatocellular uptake of unconjugated bilirubin

23
Q

crigler najjar

A

enzyme mutation - defective conjugation of bilirubin

very high unconjugated

24
Q

dubin johnson

A

black stool

defective secretion by hepatocyte of conjugated bilirubin

elevated direct and indirect
-total levels 5-10

25
Q

post-hepatic

A

impaired excretion
-mechanical obstruction

clay colored stool - decreased urobilin/stercobilin in stool

increased conjugated bilirubin in serum

HEME/LYMPH (11 decks)

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