WBC Disorders I

Question 1

MMEG

Answer 1

myeloid
megakaryocyte
erythrocyte
granulocyte

all same stem cell lineage

Question 2

lymphocyte

Answer 2

T cell
B cell
NK cells

Question 3

NK cell

Answer 3

granular cytoplasm - can be confused with other granulocytes

Question 4

source of HSCs

Answer 4

mesonephros

-third month of embryogenesis migrate to liver

Question 5

EMH

Answer 5

extramedullary hematopoiesis

-blood cell formation not in bone marrow medulla

Question 6

fourth month of embryogenesis

Answer 6

migration to bone marrow

Question 7

at puberty

Answer 7

hematopoiesis to axial skeleton

Question 8

cord blood HSCs

Answer 8

placenta

Question 9

bone marrow bx

Answer 9

PSIS in adults

children - used to do sternum

Question 10

red marrow

Answer 10

hematopoiesis

Question 11

metastatic prostate

Answer 11

to vertebra

Question 12

leukocyte

Answer 12

residence in tissue

monocytes
granulocytes
lymphocytes

Question 13

granulocytes

Answer 13

eosinos
basos
neutros

Question 14

upper limit WBCs

Answer 14

10,000

Question 15

granulocyte count

Answer 15

40-70%

Question 16

RBC normal

Answer 16

4-5

Question 17

platelet upper limit

Answer 17

450,000

Question 18

bleeding

Answer 18

platelet under 10,000

can give platelet pack

Question 19

sinusoids

Answer 19

fenestrated endothelium

megakaryocyte sticks through and releases platelets

vascular structure - allows movement of cells into vascular space

in bone marrow

Question 20

large cells with abundant cyanophilic cytoplasm

Answer 20

megakaryocytes

Question 21

bone marrow

Answer 21

1:1 adipose to blood cells

Question 22

platelet life span

Answer 22

7-10 days

eliminated by phagocytosis in spleen

Question 23

nucleated RBC in peripheral blood

Answer 23

abnormal

Question 24

erythropoietin

Answer 24

released from peritubular capillary lining of kidney and liver

Question 25

above Hg of 10

Answer 25

EPO released constant rate

increased release with Hg below 10

Question 26

EPO release

Answer 26

regulated by monitoring PO2

Question 27

reticulocyte

Answer 27

not-nucleated RBC

remnant ER and ribosomes that form reticulum in cytoplasm

• larger than RBC
• circulate 2-3 days

normally 2% of population

Question 28

RBC synthesis

Answer 28

4 days

200 million/day

Question 29

life span RBC

Answer 29

120 days

Question 30

red pulp

Answer 30

of spleen

• spleen sinusoids
• site of RBC destruction

iron content is recycled

Question 31

3 compartments of monocytes

Answer 31

bone marrow, blood, tissue

Question 32

monocyte

Answer 32

intravascular transit form of cells that become macrophages

24 hour transit

Question 33

microglia

Answer 33

CNS macros

Question 34

kupffer

Answer 34

liver macros

Question 35

alveolar

Answer 35

lung macros

Question 36

osteoclasts

Answer 36

bone macros

Question 37

metamyelocyte

Answer 37

before band cells in granulocyte proliferation

has indented nucleus

Question 38

normal neutrophil

Answer 38

3-5 lobes nucleus

Question 39

basophil

Answer 39

release histamine and leukotriene

Question 40

helper T cells

Answer 40

CD4

Question 41

cytotoxic T cells

Answer 41

CD8

Question 42

most circulating lymphocytes

Answer 42

T cells

80%

Question 43

B cell life span

Answer 43

hours to days

Question 44

T cell life span

Answer 44

days to years

Question 45

NK cell markers

Answer 45

CD56

CD16

Question 46

B cell marker

Answer 46

CD19

Question 47

blood volume

Answer 47

5 liters

Question 48

unit of blood

Answer 48

1/10 of blood volume