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HEME/LYMPH > WBC Disorders IV > Flashcards

WBC Disorders IV Flashcards

1
Q

most common cancer of children

A

acute lymphoblastic leukemia/lymphoma

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2
Q

B-ALLs

A

children - age 3 peak

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3
Q

t(12;21)

A

B-ALL

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4
Q

T-ALLs

A

adolescents peak

-thymic

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5
Q

GOF mutation NOTCH1

A

T-ALL

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6
Q

TdT positive

A

ALLs

-B and T cell

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7
Q

TdT, CD19, CD10, CD20

A

B-ALL

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8
Q

TdT, CD1, CD2, CD5, CD7, CD3, CD4

A

T-ALL

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9
Q

ALL

A

more in boys and whites

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10
Q

hyperdiploidy

A

90% of ALLs

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11
Q

more common ALL

A

B-ALL

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12
Q

B-ALL prognosis

A

aggressive

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13
Q

T-ALL prognosis

A

aggressive

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14
Q

pancytopenia

A

B-ALL

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15
Q

thymic mass and bone marrow involvement

A

T-ALL

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16
Q

ALL clinical

A

abrupt, stormy onset

  • fatigue, fever, bleeding
  • anemia, neutropenia, thrombocytopenia

mass effects - bone pain, lymphademopathy, splenomegaly, hepatomeglay

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17
Q

testicular enlargement

A

ALL

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18
Q

compression of SVC and airways

A

T-ALL

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19
Q

CNS manifestations

A

ALL

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20
Q

ALL and AML

A

very similar clinically
-immunophenotypically distinct

abrupt onset
fever, infection, bleeding
mass effects (more ALL)
CNS sx (more ALL)

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21
Q

most common cause of cancer death in children

A

ALL

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22
Q

favorable ALL prognosis

A 
age 2-10
low WBC
hyperdiploidy
trisomy 4, 7, 10
t(12;21)
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23
Q

unfavorable ALL prognosis

A

under age 2
adolescent/adult
peripheral blasts > 100,000
t(9;22) philadelphia

24
Q

philadelphia chromosome

A

t(9;22)

BCR-ABL fusion mutation

25
Q

age 2-10

A

good ALL prognosis

26
Q

trisomy 4, 7, 10

A

good ALL prognosis

27
Q

t(12;21)

A

good ALL prognosis

28
Q

hyperdiploidy

A

good ALL prognosis

29
Q

CLL vs. SLL

A

differ only in degree of peripheral blood lymphocytosis

-CLL > 5,000

30
Q

most common leukemia of adults in western world

A

CLL

-chronic lymphocytic leukemia

31
Q

SLL

A

small lymphocytic lymphoma

32
Q

dry tap

A

hairy cell leukemia

33
Q

middle age man with hepatosplenomegaly

A

hairy cell leukemia

34
Q

CD19/CD20

CD23/CD5

A

CLL/SLL

35
Q

deletion 13q, 11q, 17p

trisomy 12q

A

CLL/SLL

36
Q

fatigable, weight loss, lymphadenopathy, hepatosplenomegaly, small monoclonal Ig spike, hemolytic anemia, hypogammaglobulinemia

A

CLL/SLL

37
Q

autoantibodies made by nonneoplastic B cells

A

causes thrombocytopenia in CLL/SLL

38
Q

proliferation centers

A

pathognomonic for CLL/SLL

loose aggregates of larger activated lymphocytes
-have mitotically active cells

39
Q

prognosis of SLLC/CLL

A

indolent

40
Q

CLL/SLL age

A

around 60yo male

often asymptomatic at diagnosis

41
Q

smudge cells

A

CLL

42
Q

richter syndrome

A

tranformation of CLL to diffuse large B cell lymphoma

  • rapidly enlarging mass in node or spleen
  • survival < 1 year
43
Q

transformation of CLL with prolymphocyte evolution to DLBCL

A

richter syndrome

bad prognosis

44
Q

most common form of indolent NHL in US

A

follicular lymphoma

45
Q

follicular lymphoma prognosis

A

indolent - incurable

survival 7-9 years

46
Q

BCL2 positive

A

follicular lymphoma

47
Q

t(14;18)

A

follicular lymphoma

IGH on 14
BCL2 on 18

48
Q

CD19, CD20, CD10, BCL6, BCL2

A

follicular lymphoma

49
Q

follicular lymphoma

A

nodular aggregates throughout lymph node

-small centrocytes and large centroblasts

50
Q

spleen in follicular lymphoma

A

image with lots of white speckles

51
Q

paratrabecular lymphoid aggregates

A

bone marrow of follicular lymphoma

52
Q

NO CD5

A

follicular lymphoma

53
Q

peripheral blood in follicular lymphoma

A

lymphocytosis

-usually < 20,000

54
Q

transformation of follicular lymphoma

A

30-50% to DLBCL

also less commonly to burkitt - myc translocations

55
Q

painless lymphadenopathy, incurable, waxing and waning course, anti-CD20 when symptomatic

A

follicular lymphoma

survival 7-9 years

HEME/LYMPH (11 decks)

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