WBC Disorders IV

Question 1

most common cancer of children

Answer 1

acute lymphoblastic leukemia/lymphoma

Question 2

B-ALLs

Answer 2

children - age 3 peak

Question 3

t(12;21)

Answer 3

B-ALL

Question 4

T-ALLs

Answer 4

adolescents peak

-thymic

Question 5

GOF mutation NOTCH1

Answer 5

T-ALL

Question 6

TdT positive

Answer 6

ALLs

-B and T cell

Question 7

TdT, CD19, CD10, CD20

Answer 7

B-ALL

Question 8

TdT, CD1, CD2, CD5, CD7, CD3, CD4

Answer 8

T-ALL

Question 9

ALL

Answer 9

more in boys and whites

Question 10

hyperdiploidy

Answer 10

90% of ALLs

Question 11

more common ALL

Answer 11

B-ALL

Question 12

B-ALL prognosis

Answer 12

aggressive

Question 13

T-ALL prognosis

Answer 13

aggressive

Question 14

pancytopenia

Answer 14

B-ALL

Question 15

thymic mass and bone marrow involvement

Answer 15

T-ALL

Question 16

ALL clinical

Answer 16

abrupt, stormy onset

• fatigue, fever, bleeding
• anemia, neutropenia, thrombocytopenia

mass effects - bone pain, lymphademopathy, splenomegaly, hepatomeglay

Question 17

testicular enlargement

Answer 17

ALL

Question 18

compression of SVC and airways

Answer 18

T-ALL

Question 19

CNS manifestations

Answer 19

ALL

Question 20

ALL and AML

Answer 20

very similar clinically
-immunophenotypically distinct

abrupt onset
fever, infection, bleeding
mass effects (more ALL)
CNS sx (more ALL)

Question 21

most common cause of cancer death in children

Answer 21

ALL

Question 22

favorable ALL prognosis

Answer 22

age 2-10
low WBC
hyperdiploidy
trisomy 4, 7, 10
t(12;21)

Question 23

unfavorable ALL prognosis

Answer 23

under age 2
adolescent/adult
peripheral blasts > 100,000
t(9;22) philadelphia

Question 24

philadelphia chromosome

Answer 24

t(9;22)

BCR-ABL fusion mutation

Question 25

age 2-10

Answer 25

good ALL prognosis

Question 26

trisomy 4, 7, 10

Answer 26

good ALL prognosis

Question 27

t(12;21)

Answer 27

good ALL prognosis

Question 28

hyperdiploidy

Answer 28

good ALL prognosis

Question 29

CLL vs. SLL

Answer 29

differ only in degree of peripheral blood lymphocytosis | -CLL > 5,000

Question 30

most common leukemia of adults in western world

Answer 30

CLL | -chronic lymphocytic leukemia

Question 31

SLL

Answer 31

small lymphocytic lymphoma

Question 32

dry tap

Answer 32

hairy cell leukemia

Question 33

middle age man with hepatosplenomegaly

Answer 33

hairy cell leukemia

Question 34

CD19/CD20 | CD23/CD5

Answer 34

CLL/SLL

Question 35

deletion 13q, 11q, 17p | trisomy 12q

Answer 35

CLL/SLL

Question 36

fatigable, weight loss, lymphadenopathy, hepatosplenomegaly, small monoclonal Ig spike, hemolytic anemia, hypogammaglobulinemia

Answer 36

CLL/SLL

Question 37

autoantibodies made by nonneoplastic B cells

Answer 37

causes thrombocytopenia in CLL/SLL

Question 38

proliferation centers

Answer 38

pathognomonic for CLL/SLL loose aggregates of larger activated lymphocytes -have mitotically active cells

Question 39

prognosis of SLLC/CLL

Answer 39

indolent

Question 40

CLL/SLL age

Answer 40

around 60yo male often asymptomatic at diagnosis

Question 41

smudge cells

Answer 41

CLL

Question 42

richter syndrome

Answer 42

tranformation of CLL to diffuse large B cell lymphoma - rapidly enlarging mass in node or spleen - survival < 1 year

Question 43

transformation of CLL with prolymphocyte evolution to DLBCL

Answer 43

richter syndrome bad prognosis

Question 44

most common form of indolent NHL in US

Answer 44

follicular lymphoma

Question 45

follicular lymphoma prognosis

Answer 45

indolent - incurable survival 7-9 years

Question 46

BCL2 positive

Answer 46

follicular lymphoma

Question 47

t(14;18)

Answer 47

follicular lymphoma IGH on 14 BCL2 on 18

Question 48

CD19, CD20, CD10, BCL6, BCL2

Answer 48

follicular lymphoma

Question 49

follicular lymphoma

Answer 49

nodular aggregates throughout lymph node | -small centrocytes and large centroblasts

Question 50

spleen in follicular lymphoma

Answer 50

image with lots of white speckles

Question 51

paratrabecular lymphoid aggregates

Answer 51

bone marrow of follicular lymphoma

Question 52

NO CD5

Answer 52

follicular lymphoma

Question 53

peripheral blood in follicular lymphoma

Answer 53

lymphocytosis | -usually < 20,000

Question 54

transformation of follicular lymphoma

Answer 54

30-50% to DLBCL also less commonly to burkitt - myc translocations

Question 55

painless lymphadenopathy, incurable, waxing and waning course, anti-CD20 when symptomatic

Answer 55

follicular lymphoma survival 7-9 years