WBC Disorders III

Question 1

naive B cells

Answer 1

SLL/CLL

also marginal zone

Question 2

plasma cells

Answer 2

multiple myeloma

Question 3

marginal zone B cells

Answer 3

marginal zone lymphoma

Question 4

germinal B cells

Answer 4

hodgkins lymphoma
burkitt lymphoma
follicular lymphoma

Question 5

class I MHC

Answer 5

CD8

HLA A, B, C

Question 6

class II MHC

Answer 6

CD4

HLA D

Question 7

nucleated cells

Answer 7

class I MHC

viral infections

Question 8

extracellular microbes

Answer 8

class II MHC

on macrophages, B cells, dendritic cells

Question 9

CD4 cells

Answer 9

Th1
Th2
Th17

Question 10

Treg cells

Answer 10

suppress immune response

Question 11

NK cells

Answer 11

kill virus infected and tumor cells

have granules

CD16, CD56

balance of activating/inhibiting factors

virus inhibit class I MHC

Question 12

follicle

Answer 12

B cell zone

Question 13

paracortex

Answer 13

T cell zone

Question 14

HEV

Answer 14

high endothelial venule

• post-capillary venous swelling
• allow lymphocyte

Question 15

mantle zone

Answer 15

surrounds germinal center

Question 16

medullar region

Answer 16

vacuolated macrophages
sinusoids
cords

Question 17

reticular fibers

Answer 17

surround germinal center

type III collagen

if stain and see these - not neoplastic, but reactive node

Question 18

lymph circulation

Answer 18

afferent - pierce capsule to subcapsular sinus

paratrabecular sinus - to cortex to medulla as medullary sinus

exit efferent at hilum

Question 19

mantle zone

Answer 19

mature B cells that are not specific for antigen

low affinity - apoptosis
high affinity - convert to plasma cells - form IgM and IgG

Question 20

KSHV

Answer 20

pleural effusion in B cell lymphoma

Question 21

EBV

Answer 21

burkitt lymphoma subsets
hodgkins
B cell lymphomas
rare NK neoplasms

Question 22

HTLV-1

Answer 22

adult T cell leukemia/lymphoma

Question 23

hodgkins

Answer 23

fever

Question 24

cyclic fever

Answer 24

B cell neoplasms

Question 25

auer rods

Answer 25

in myeloid cells

Question 26

thrombocytopenia

Answer 26

with acute leukemia

Question 27

normal platelet counts

Answer 27

hodgkin and NHL

Question 28

bone marrow suppression

Answer 28

in lymphocytic leukemias

Question 29

most lymphoid neoplasms

Answer 29

B cell origin

Question 30

BALL/ALL

Answer 30

immature B and T cells

Question 31

burkitt

Answer 31

germinal center mature B cells

Question 32

DLBCL

Answer 32

mature B cells

Question 33

extranodal margin zone lymphoma

Answer 33

memory mature B cells

Question 34

follicular lymphoma

Answer 34

mature B cells

Question 35

hairy cell leukemia

Answer 35

memory mature B cells

Question 36

mantle cell lymphoma

Answer 36

mature B cells

Question 37

multiple myeloma

Answer 37

mature B cells

Question 38

SLL/CLL

Answer 38

mature B cells

Question 39

mycosis fungoide/sezary

Answer 39

mature helper T cells

Question 40

large, granular lymphocyte leukemia

Answer 40

T cell and NK cell types

Question 41

anaplastic large cell lymphoma

Answer 41

cytotoxic T cells

Question 42

adult T cell lymphoma/leukemia

Answer 42

helper T cells

Question 43

peripheral T cell lymphoma, unspecified

Answer 43

helper and cytotoxic T cells

Question 44

extranodal NK/T cell lymphoma

Answer 44

NK-cell or cytotoxic (rare) T cells

Question 45

multiple myeloma

Answer 45

plasma cell

Question 46

hodgkins subtypes

Answer 46

1 nodular sclerosis
2 mixed cellularity
3 lymphocyte rich
4 lymphocyte depleted
5 lymphocyte predominant

1-4 - same immunophenotype
4,5 - bad prognosis
1-3 - good prognosis