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HEME/LYMPH > WBC Disorders III > Flashcards

WBC Disorders III Flashcards

1
Q

naive B cells

A

SLL/CLL

also marginal zone

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2
Q

plasma cells

A

multiple myeloma

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3
Q

marginal zone B cells

A

marginal zone lymphoma

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4
Q

germinal B cells

A

hodgkins lymphoma
burkitt lymphoma
follicular lymphoma

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5
Q

class I MHC

A

CD8

HLA A, B, C

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6
Q

class II MHC

A

CD4

HLA D

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7
Q

nucleated cells

A

class I MHC

viral infections

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8
Q

extracellular microbes

A

class II MHC

on macrophages, B cells, dendritic cells

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9
Q

CD4 cells

A

Th1
Th2
Th17

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10
Q

Treg cells

A

suppress immune response

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11
Q

NK cells

A

kill virus infected and tumor cells

have granules

CD16, CD56

balance of activating/inhibiting factors

virus inhibit class I MHC

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12
Q

follicle

A

B cell zone

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13
Q

paracortex

A

T cell zone

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14
Q

HEV

A

high endothelial venule

  • post-capillary venous swelling
  • allow lymphocyte
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15
Q

mantle zone

A

surrounds germinal center

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16
Q

medullar region

A

vacuolated macrophages
sinusoids
cords

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17
Q

reticular fibers

A

surround germinal center

type III collagen

if stain and see these - not neoplastic, but reactive node

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18
Q

lymph circulation

A

afferent - pierce capsule to subcapsular sinus

paratrabecular sinus - to cortex to medulla as medullary sinus

exit efferent at hilum

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19
Q

mantle zone

A

mature B cells that are not specific for antigen

low affinity - apoptosis
high affinity - convert to plasma cells - form IgM and IgG

20
Q

KSHV

A

pleural effusion in B cell lymphoma

21
Q

EBV

A

burkitt lymphoma subsets
hodgkins
B cell lymphomas
rare NK neoplasms

22
Q

HTLV-1

A

adult T cell leukemia/lymphoma

23
Q

hodgkins

A

fever

24
Q

cyclic fever

A

B cell neoplasms

25
Q

auer rods

A

in myeloid cells

26
Q

thrombocytopenia

A

with acute leukemia

27
Q

normal platelet counts

A

hodgkin and NHL

28
Q

bone marrow suppression

A

in lymphocytic leukemias

29
Q

most lymphoid neoplasms

A

B cell origin

30
Q

BALL/ALL

A

immature B and T cells

31
Q

burkitt

A

germinal center mature B cells

32
Q

DLBCL

A

mature B cells

33
Q

extranodal margin zone lymphoma

A

memory mature B cells

34
Q

follicular lymphoma

A

mature B cells

35
Q

hairy cell leukemia

A

memory mature B cells

36
Q

mantle cell lymphoma

A

mature B cells

37
Q

multiple myeloma

A

mature B cells

38
Q

SLL/CLL

A

mature B cells

39
Q

mycosis fungoide/sezary

A

mature helper T cells

40
Q

large, granular lymphocyte leukemia

A

T cell and NK cell types

41
Q

anaplastic large cell lymphoma

A

cytotoxic T cells

42
Q

adult T cell lymphoma/leukemia

A

helper T cells

43
Q

peripheral T cell lymphoma, unspecified

A

helper and cytotoxic T cells

44
Q

extranodal NK/T cell lymphoma

A

NK-cell or cytotoxic (rare) T cells

45
Q

multiple myeloma

A

plasma cell

46
Q

hodgkins subtypes

A 
1 nodular sclerosis
2 mixed cellularity
3 lymphocyte rich
4 lymphocyte depleted
5 lymphocyte predominant

1-4 - same immunophenotype
4,5 - bad prognosis
1-3 - good prognosis

HEME/LYMPH (11 decks)

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