Pharmacology of Anemia

Question 1

cyanocobalamin

Answer 1

Vit B12

Question 2

hydroxocobalamin

Answer 2

Vit B12

Question 3

iron dextran

Answer 3

parenteral iron

Question 4

iron sucrose complex

Answer 4

parenteral iron

Question 5

sodium ferric gluconate complex

Answer 5

parenteral iron

Question 6

deferoxamine

Answer 6

iron chelator

Question 7

defasirox

Answer 7

iron chelator

Question 8

epoetin alpha

Answer 8

ESA

Question 9

darbepoetin alpha

Answer 9

ESA

Question 10

filgrastim

Answer 10

G-CSF

Question 11

pegfilgrastim

Answer 11

G-CSF

Question 12

sargramostim

Answer 12

GM-CSF

Question 13

oprelvekin

Answer 13

megakaryocyte GF

Question 14

romiplostim

Answer 14

megakaryocyte GF

Question 15

low free iron

Answer 15

inhibits apoferritin synthesis

-less stoarge

Question 16

high free iron

Answer 16

stimulate apoferritin synthesis

-more storage

Question 17

oral iron therapy

Answer 17

empty stomach

Question 18

adverse oral iron therapy

Answer 18

GI discomfort, black stool

Question 19

parenteral iron therapy

Answer 19

pt cannot tolerate oral iron or extensive chronic anemia

malabsorption syndrome, inflammatory bowel disease

Question 20

colloid containing particles with core of iron oxyhydroxide surrounded by carbohydrates

Answer 20

parenteral iron

Question 21

iron dextran adverse

Answer 21

HA, fever, light headed, nausea

ANAPHYLAXIS - give test dose

Question 22

acute iron toxicity

Answer 22

young child eats iron tabs

tx - deferoxamine

Question 23

red cell transfusions over time

Answer 23

chronic iron toxicity

tx - intermittent phlebotomy

Question 24

deferasirox

Answer 24

iron chelator

reduces liver iron concentrations
-but no data on decreased heart

Question 25

source of B12

Answer 25

microbial synthesis

Question 26

absorption of B12

Answer 26

complexed with intrinsic factor

• from parietal cells
• absorption in distal ileum

Question 27

require B12

Answer 27

synthesis of methionine