Pharmacology of Anemia Flashcards
cyanocobalamin
Vit B12
hydroxocobalamin
Vit B12
iron dextran
parenteral iron
iron sucrose complex
parenteral iron
sodium ferric gluconate complex
parenteral iron
deferoxamine
iron chelator
defasirox
iron chelator
epoetin alpha
ESA
darbepoetin alpha
ESA
filgrastim
G-CSF
pegfilgrastim
G-CSF
sargramostim
GM-CSF
oprelvekin
megakaryocyte GF
romiplostim
megakaryocyte GF
low free iron
inhibits apoferritin synthesis
-less stoarge
high free iron
stimulate apoferritin synthesis
-more storage
oral iron therapy
empty stomach
adverse oral iron therapy
GI discomfort, black stool
parenteral iron therapy
pt cannot tolerate oral iron or extensive chronic anemia
malabsorption syndrome, inflammatory bowel disease
colloid containing particles with core of iron oxyhydroxide surrounded by carbohydrates
parenteral iron
iron dextran adverse
HA, fever, light headed, nausea
ANAPHYLAXIS - give test dose
acute iron toxicity
young child eats iron tabs
tx - deferoxamine
red cell transfusions over time
chronic iron toxicity
tx - intermittent phlebotomy
deferasirox
iron chelator
reduces liver iron concentrations
-but no data on decreased heart
source of B12
microbial synthesis
absorption of B12
complexed with intrinsic factor
- from parietal cells
- absorption in distal ileum
require B12
synthesis of methionine
