Wbc Abnormalities Flashcards

0
Q

What are three types of neutrophilia?

A

Transient, stress, inflammatory

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1
Q

What is an increase in neutrophils called?

A

Neutrophilia

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2
Q

What is transient neutrophilia causes by?

A

Adrenaline (epinephrine) as a result if fear, exercise, or excitement

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3
Q

What is the marginal neutrophil pool?

A

Neutrophils that stick to vessel walls and can enter circulation in response to stimuli

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4
Q

Does transient neutrophilia have a left shift?

A

No

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5
Q

What is transient neutrophilia common in and rare in?

A

Common in cats, rare in dogs

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6
Q

What species is stress neutrophilia common in?

A

Dogs

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7
Q

Is the a left shift in stress neutrophilia?

A

Usually no

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8
Q

What can steroids do in stress neutrophilia?

A

Can cause increase in neutrophil transit time and decrease neutrophil movement into tissues

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9
Q

What causes inflammatory neitrophilia?

A

Tissue demand for phagocytes

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10
Q

What usually causes a greater response of inflammatory neutrophilia?

A

Localized purulent diseases

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11
Q

Is a left shift common in inflammatory neutrophilia?

A

Yes

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12
Q

What is a decrease in neutrophils called?

A

Neutropenia

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13
Q

What are two reasons for neutropenia?

A

Excessive usage and decreased production

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14
Q

What cause excessive usage neutropenia?

A

Neutrophil movement into tissues are greater than the bone marrows ability to release them

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15
Q

What are six diseases that can cause neutropenia?

A

Parvovirus, feline pan leukopenia, distemper, FELV, chemical toxic irises, genetic disorders

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16
Q

What can cause toxic changes in neutrophils?

A

Toxemia, severe bacterial infections and/or inflammation

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17
Q

What are Doehle bodies?

A

Blue gray cytoplasmic inclusions

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18
Q

What are four other types of toxic changes in neutrophils?

A

Diffuse cytoplasmic Basophilic, cytoplasmic vacuoles, increased cell size, toxic granulation

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19
Q

What toxic change in neutrophils are most common in horses?

A

Toxic granulation

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20
Q

What is an increase in lymphocytes called?

A

Lymphocytes is

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21
Q

What are three causes of lymphocytes is?

A

Physiologic ( same as neutrophilia), chronic infections, lymphosarcoma

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22
Q

What is a left shift?

A

7300 bands/ul

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23
Q

What can calm someone does when stressed?

A

Corticosteroids

24
Q

What’s the difference between toxic neutrophils and monocytes?

A

Toxic neutrophils will have a dark, dense nuclear

25
Q

Do enlarged lymph nodes mean lymphocytosis?

A

Not necessarily

26
Q

What is a decrease in lymphocytes mean?

A

Lymphopenia

27
Q

What are four causes of lymphopenia?

A

Stress/corticosteroid
Loss of lymph
Immunodeficiency
Impaired lymphopoiesis

28
Q

Describe stress/corticosteroid lymphopenia

A

Occurs in pain, stressful disorders or debilitating diseases

29
Q

When will steroid therapy cause maximum decrease with lymphopenia?

A

2-4 hours

30
Q

When will lymphocytes return to normal after steroid therapy in lymphopenia?

A

24 hours

31
Q

How long is required for lymphocytes to return to normal after stopping log term steroid therapy?

A

2-3 days

32
Q

Describe loss of lymph lymphopenia

A

Ruptured or damaged lymph ducts

33
Q

What are two immunodeficiency diseases that cause lymphopenia in cats?

A

FELV and FIV

34
Q

What immuno deficient disease causes lymphopenia in other species?

A

Congenital T cell immuno deficiencies

35
Q

What can cause impaired lymphopoiesis? 4

A

Cancer, chemotherapy, prolonged steroid treatment, irradiation

36
Q

What is the most common finding in animal leukograms?

A

Lymphopenia

37
Q

How many dogs and cats die of lymphopenia?

A

1/3 of dogs and 1/2 of cats

38
Q

What is an increase of monocytes called?

A

Monocytes is

39
Q

What are two causes of monocytosis?

A

Corticosteroid/stress and tissue demand

40
Q

What is seen with stress induced monocytosis? 3

A

Neutrophilia w/I left shift
Lymphopenia
Eosinopenia

41
Q

What species is stress monocytosis common in?

A

Dogs

42
Q

Describe tissue demand of monocytosis

A

Demand for phagocytosis of large particulate debris and conditions of increased cellular immunity

43
Q

What can cause tissue demand in monocytosis? 4

A

Purulent infections: pyrometers, necrosis, internal hemorrhage, hemolytic disease

44
Q

What is a decrease in monocytes called?

A

Monocytopenia

45
Q

What two leukograms are not clinically useful?

A

Monocytopenia and Basopenia

46
Q

What is an increase in eosinophils called?

A

Eosinophilia

47
Q

What causes eosinophilia?

A

Not sure

48
Q

What does eosinophilia result from?

A

Antigen-antibody interaction in the tissues (skin, lungs, GI)

49
Q

When is eosinophilia seen?

A

Parasite infections or when host tissue/parasite contact is long

50
Q

Does finding parasites in decal of adult animal cause for increase?

A

Not always

51
Q

What is a decrease in eosinophils called?

A

Eosinopenia

52
Q

What can cause eosinopenia?

A

Corticosteroids

53
Q

When will corticosteroids cause eosinopenia?

A

2-3 hours after administration

54
Q

When will pretreatment levels of eosinopenia return? Shirt term and longn term

A

24 hours short, 72 hours long term

55
Q

What so you call an increase in basophils?

A

Basophilia

56
Q

What can you see Basophilia with?

A

Hyperlipidemia and eosinophilia during disorders of long standing antibody stimulation

57
Q

What is chronic dirofilarious?

A

Long standing antibody stimulation