Erythrocyte Abnormalities

Question 0

What are the signs of anemia? (6)

Answer 0

Decreased exercise tolerance, lethargy, depression, pale mucous membranes, increased heart and respiration times

Question 1

What is anemia?

Answer 1

Characterized by decreased RBC, PVC, or decreased ability to transport 02 to the tissues

Question 2

How are anemias classified?

Answer 2

Morphology, disease symptoms and bone marrow response.

Question 3

Can you classify anemia with only one criteria?

Answer 3

No

Question 4

What are the three indices?

Answer 4

MCV, MCHC, MCH

Question 5

What is MCV?

Answer 5

Cell size, micro, macro, or normocryptic

Question 6

What is MCHC?

Answer 6

Stain intensity, normo or hypochromic

Question 7

What is MCH?

Answer 7

No practical value, lab quality control.

Question 8

Based on bone marrow response what can you conclude?

Answer 8

Regenerative or non-regenerative

Question 9

What is regenerative anemia?

Answer 9

Erythropoiesis is taking place and bone marrow is responding to anemia

Question 10

What will you see with increased erythropoiesis?

Answer 10

Increase in immature RBC in circulation

Question 11

What can point to regenerative anemia?

Answer 11

Reticulocytes, increased polychromasia, anisocytosis, and erythroid hyperplasia in the bone marrow

Question 12

What can the ability for the bone marrow to respond indicate?

Answer 12

Hemorrhage or hemolysis

Question 13

How long does it take for a regenerative response to be seen in blood?

Answer 13

2-5 days

Question 14

What is non-regenerative anemia?

Answer 14

Bone marrow is unable to respond

Question 15

What will you not see with non-regenerative anemia?

Answer 15

Polychromasia and reticulocytosis

Question 16

What can cause non regenerative anemia?

Answer 16

Decreased erythropoietin, inadequate bone marrow response, or ineffective RBC production

Question 17

What is the most common cause if non regenerative anemia in cats?

Answer 17

FeLV

Question 18

If there are Nucleated RBC but no Reticulocytes what does thine mean?

Answer 18

Bone marrow disease such as FIV, Cancer, or viral

Question 19

What are five types of anemia?

Answer 19

Hemorrhagic, iron deficiency, Vit B12/frolic acid deficiency, aplastic.

Question 20

What is hemorrhagic anemia?

Answer 20

Results from loss of substantial quantities of blood.

Question 21

How long can it take to recover from hemorrhagic anemia?

Answer 21

1-2 weeks by erythropoiesis

Question 22

What can macro/hypo hemorrhagic anemia indicate?

Answer 22

Remission

Question 23

What will the indices look like in hemorrhagic anemia?

Answer 23

Increased MCV, decreased MCHC

Question 24

What is iron deficiency anemia?

Answer 24

Excessive loss, deficient intake, or poor absorption of iron.

Question 25

What will the RBC look like in iron deficient anemia?

Answer 25

Small and contain less hemoglobin

Question 26

What breed has cells that look like iron deficient cells?

Answer 26

Akitas

Question 27

What is frolic acid deficiency

Answer 27

Inability to absorb adequate amounts of Vit B12

Question 28

What will the RBC look like with frolic acid deficiency?

Answer 28

Small in number, larger than normal, more fragile

Question 29

What can cows have that look similar to frolic acid deficiency?

Answer 29

Cobalt deficiency

Question 30

What is aplastic anemia?

Answer 30

Inadequate production of RBC due to inhibition or destruction if red bone marrow

Question 31

What can cause aplastic anemia?

Answer 31

Radiation, toxins, medications, chloramphenicol

Question 32

What is autoimmune hemolytic anemia?

Answer 32

Body produces antibodies against antigens on RBC surface. Ab coat RBC surface and the RBC are removed from circulation perminently.

Question 33

What can accelerated RBC destruction cause?

Answer 33

Autoimmune hemolytic anemia

Question 34

What causes autoimmune hemolytic anemia?

Answer 34

Can be primary disease or associated with other diseases (bacterial, viral, rickettsial)

Question 35

What is the most common cause of regerative anemia in dogs?

Answer 35

Autoimmune hemolytic anemia

Question 36

What will the RBC look like with autoimmune hemolytic anemia?

Answer 36

Spherocytes