Thrombocytes Flashcards

0
Q

What is the function to thrombocytes?

A

Absorb and carry plasma factors required for formation of fibrin and contributes to hemostasis

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1
Q

What does a thrombosite look like?

A

Non-Nucleated, variable size, pale blue with purple/pink granules, tend to be sticky

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2
Q

What is a megakaryocyte?

A

Largest cell in bone marrow

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3
Q

How are thrombocytes formed?

A

In red bone marrow, are fragments of megakaryocyte

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4
Q

How many platelets do canines have?

A

200,000-500,000/ul

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5
Q

How many platelets do cats have?

A

300,000-800,000/ul

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6
Q

How many platelts do horses have?

A

800,000-300,000/ul

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7
Q

How many platelets are needed to make a clot?

A

50,000/ul

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8
Q

What is hemostasis?

A

Arrest of bleeding or circulation

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9
Q

When is hemostasis initiated?

A

When vascular injury disrupts blood vessels exposing surrounding tissue to flowing blood

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10
Q

What is chemo taxis?

A

Use of chemicals to attract or repel something

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11
Q

What are three things that work together to stop bleeding?

A

Blood vessels, platelets, clotting factors

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12
Q

What is collagen?

A

Insoluble protein found in connective tissue

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13
Q

What makes a platelet plug in an injured vessel?

A

Platelets adhere to outside tissue and release chemicals that cause platelet surfaces to become sticky and collect more platelets and also release substances for Vaal constriction

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14
Q

What are extrinsic factors?

A

Ingredients found outside the vessels

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15
Q

What are thromboplstins?

A

They accelerate the clotting mechanisms

16
Q

What are intrinsic factors?

A

All components necessary for clotting are present in normal blood but are slow.

17
Q

What are two extrinsic factors?

A

Collagen and thromboplastins

18
Q

What are two intrinsic factors?

A

Clotting factors and platelets

19
Q

Explain the cascade of coagulation

A

Extrinsic factors: collagen, and thromboplastkns to accelerate the process.
Intrinsic factors: prothrombin will creat thrombin, fibrinogen will combine with thrombin and creat fibrin wich will join with platelets to creat the clot

20
Q

How do the clots retract?

A

Fibrin mesh work will shrink and become more dense and stronger and push serum out.

21
Q

Explain clot dissolution

A

Enzyme plasmin (fibrinolysin) is activated by damaged tissues and thrombin from inactivated form plasminogen. Plasmin is breaks down clot after a few days to build up

22
Q

What are two substances that can prevent clots?

A

Heparin and plasmin

23
Q

What prevents platelets from adhering?

A

Smooth lining of vessels

24
Q

What are intravascular clots?

A

Clots that occasionally occur within the vasculature system

25
Q

What is thrombus?

A

A clot that adheres to a vessel wall

26
Q

What can a thrombus do?

A

Can block blood supply to the heart and cause heart damage

27
Q

What is an embolus?

A

Intravascular clot floating in the blood and can be lodged in small vessels blocking blood flow and causing damage