Plasma and RBC Flashcards

0
Q

How do blood components settle?

A

According to weight

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1
Q

What are the 9 functions of blood?

A
Transport nutrients from GI to body tissues
Carries O2 from lungs to tissues
Carried CO2 from tissues to lungs
Carries waste from tissues to kidneys
Temperature control
Water balance
Ph regulation
Clotting factors and ability
Defense system from disease
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2
Q

What are the four components to while blood?

A

Plasma, erythrocyte, leukocyte, thrombocytes

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3
Q

How much of plasma is water?

A

90%

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4
Q

What makes up 10% of plasma?

A

Dissolved particles such as electrolytes, hormones, waste products, protiens, etc.

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5
Q

What is the function if plasma?

A

Bathes all cells in body and protects them from external environment and also acts as a buffer to stabilize pH

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6
Q

What are two plasma protiens?

A

Albumin and globulin

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7
Q

What plasma protien is most abundant and produced by the liver?

A

Albumin

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8
Q

What is albumin important for?

A

Binding and transporting

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9
Q

What are the three types of globulin?

A

Alpha, beta, and gamma

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10
Q

Which globulins are used for transport?

A

Alpha and mostly beta

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11
Q

What are gamma globulins also known as?

A

Immunoglobulins or antibodies

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12
Q

Which globulin is not produced in the liver?

A

Gamma

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13
Q

What globulin is produced by plasma and lymphocytes when stimulates by antigens?

A

Gamma

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14
Q

What are gamma globulins in charge of?

A

Immunity and resistance to disease and also provides the immune respone

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15
Q

What does an immune response do?

A

Antibodies to react against antigens such as bacteria or foreign particles. It will either neutralizes the antigen or helps break it down

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16
Q

What is an antigen?

A

Protien ID flags, helps identify self from non self

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17
Q

What are antibodies?

A

Produced to neutralize foreign antigens

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18
Q

What is the function of plasma protiens?

A

Transportation, clotting, immune response, buffering (helps prevent changes in pH)

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19
Q

What is serum?

A

Plasma - fibrinogen and clotting factors

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20
Q

What type of tube would be used for getting serum?

A

A red top tube

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21
Q

What shape are erythrocytes?

A

Bi concave discs

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22
Q

What is the central palor?

A

Where cell is thinnest in the middle

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23
Q

Why are rbc shaped like they are?

A

Allows more surface area

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24
What is essential to the transport of oxygen and co2?
Hemoglobin
25
What is serum?
Plasma - fibrinogen and clotting factors
26
What type of tube would you use for serum?
Red top tube
27
What shape do RBC's have?
Bi concave
28
Why do RBC's have a central palor?
For more surface area
29
What is the function of RBC's?
Specialized for O2 transport
30
How many hemoglobins does a RBC have?
300 million
31
What is hemoglobin made up of?
1protien 4 non protiens
32
How many iron atoms are on one hemoglobin?
Four
33
How many oxygen molecules are on one hemoglobin?
Four
34
What is the term for a hemoglobin that has combined with oxygen?
Oxyhemoglobin
35
What is hemoglobin also responsible for?
Co2 transport
36
What does the Co2 combine with for transport on a hemoglobin?
Protien globin
37
What do undifferentiated stem cells produce?
All formed elements of blood
38
What is puripotent?
Capable of becoming many different types of cells
39
Where are stem cells found?
Inside red bone marrow
40
What happens in general as cells mature?
They become smaller and lose their nucleus
41
What does blue cytoplasm mean?
Younger red blood cells that contain large amounts of RNA
42
What makes young RBCs blue?
RNA
43
What is the nucleoli?
Dark spot on the nucleus of a young RBC
44
What does a nucleoli mean?
Signs of Metabolic growth and activity
45
What regulates erythropoiesis?
Erythropoietin
46
What is erythropoietin?
Hormone produced by the kidneys
47
What can stimulate eruthropoiesis?
Decreased oxygen or hemoglobin concentration
48
What type of RBC has a nucleoli, linear chromatin, and a distinct blue tint?
Rubriblast
49
What type of RBC has a coarsening of chromatin, disappearing nucleoli and a reddish tinge from hemoglobin beginning to appear?
Prorubricyte
50
What would you call a Nucleated RBC?
Metarubricyte
51
When does a RBC lose it's nucleus?
Between the metarubricyte and polychromatophil
52
What does a polychromatophil look like?
No nucleus, blue tinge, larger than a mature RBC.
53
What will a polychromatophil look like when it is stained?
Basophilic stippling
54
In a smear what is a normal amount of polychromatophils to see?
1-2%
55
What could an increase of chromatophils indicate?
Body responding to decreased RBC's such as anemia
56
How long will a polychromatophil circulate before t matures?
1-2 days
57
What species do not release polychromatophils?
Horses
58
What do monocytes grow up into?
Macrophages
59
How long is a RBC life span?
90-120 days
60
What does the globin break down to?
Amino acids to make new protiens
61
What does heme recycle to?
Iron is stripped away and the heme is recycled to make new heme
62
What is left over after the heme and globin have been recycled?
Biliverdin
63
What is heme - iron?
Biliverdin
64
What happens to biliverdin?
It gets converted into in conjugated bilirubin, then goes to the liver and becomes conjugated bilirubin, and then becomes bilinogen in feces and uronelinogen in urine
65
What does bilirubin do?
Emulsifies and breaks down fats
66
What color is bilirubin?
Yellow
67
What does rouleaux mean?
Stack of coins that have fallen over. Chain formation
68
What does crenation mean?
Moisture sucked out and makes cells shrivel up
69
What do canine RBC look like? (5)
Large, uniform in size, central pallor, rouleaux is fairly common, crenation is not to common
70
What does feline RBC look like?
Smaller than dogs, crenation is common, mild anisocytosis
71
What are Howell jolly bodies?
Nuclear remenants
72
What percent of cells in felines are Howell jolly bodies?
1%
73
What are hienz bodies?
Denatured hemoglobin
74
How often do hienz bodies occur?
Approximately 10% of cells
75
What do equine RBC's look like?
About the size of cat cells, lack central pallor, rouleaux common
76
What do bovine RBC's look like?
About the size of cat cells, anisocytosis is common, slight central pallor, crenation is common
77
What does ovine blood look like?
Uniformly bi concave, small central concavity, anisocytosis common
78
What does caprine RBC's look like?
Sickle shape, smallest of RBC's in domesticated animals, lack of central pallor, no rouleaux, and poikilocytosis.
79
What is poikilocytosis?
Variation in shape
80
What is a depranocyte?
Sickle shaped