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Patho A > WBC > Flashcards

WBC Flashcards

1
Q

Two.types of disorder of white cells

A

Proliferative disorder

Leukopenias

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2
Q

Types of proliferative disorder

A

Reactive proliferative

Neoplastic proliferation

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3
Q

Impaired granulocytic differentiation

A

Kostmann syndrome

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4
Q

Causes a toxic effect on granulocytic precursor

A

Chlorpromazine

Phenylbutazone

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5
Q

This is a ulcerating necrotizing lesions of the oral cavity

A

Agranulocytoc angina

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6
Q

Microscopic findings in leukocytosis

A

Toxkc granules
Dohle bodies
Cytoplasmic vacuoles

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7
Q

Due to humoral immune response

Naive b cells and mitotic spindles

RA,toxoplasmosis and early HIV

A

Follicular hyperplasia

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8
Q

Prominent in nodes draining cancer

A

Reticular hyperplasia

Sinus histiocytosis

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9
Q

Common cause of hemophagocytic lymphohistiocytes

A

EBV

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10
Q

Common cause of white cell neoplasia

A

Translocation

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11
Q

Genetic diseases that can increase risk of acute leukemia

A

Bloom syndrome
Fanconi anemia
Ataxic telangiectasia

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12
Q

This is found in the subset of burkitt lymphoma

A

EBV

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13
Q

Best diagnosis for lymphoid neoplasm

A

Biopsy

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14
Q

Most common cause of cancer in children

A

ALL

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15
Q

Commonly seen in chromosomal changes in ALL

A

Hyperploidy

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16
Q

What is the morphology of the ALL

A

Hypercellular and packed lymphoblast

Nuclei chromatin delicate and finely stippled

17
Q

Worse prognosis of ALL

A

Less than 2yr old
Presentation in adulthood
+PH chromosome

18
Q

Most common leukemia in adults

A

CLL

19
Q

Also known as richter syndrome

A

Diffuse large b cell lymphoma

20
Q

Pathogenesis hallmark of Follicular lymphoma

A

Translocation 14 and 18

21
Q

Two principal cells seen in Follicular lymphoma

A

Centrocyte

Centroblast

22
Q

Two types of plasmablasts

A

Flame cells

Mott cells

23
Q

Most important clinical feature of multiple myeloma

A

Bence jones proteinuria

Myeloma kidney

24
Q

This is localized
Orderly spread
No extranodal presentation r

A

Hodgkin Lymphoma

25
Q

Most common form of hodgkin lymphoma

A

Nodular sclerosis

26
Q

This resembles a popcorn kernel appearance

A

Lymphocyte predominant type

27
Q

Diagnosis of AML

A

Presence of at least 20% of myeloid blast

Auer rods

28
Q

What are morphologic findings seen in MDS

A

Pseudo pelger huet

Pawn ball megakaryocyte

Blast cells

29
Q

Morphologic finding of primary myelofibrosis

A

Dacrocyte teardrop shaped cell

Patho A (15 decks)

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