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Patho A > RBC > Flashcards

RBC Flashcards

1
Q

How do you asses acute blood loss

A

Reticulocytosis

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2
Q

When would you diagnose chronic anemia

A

Iron reserves are depleted

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3
Q

Clinical features of extravascular hemolysis

A

Anemia
Splenomegaly
Jaundice

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4
Q

Causes of intravascular hemolysis

A

Mechanical injury
Complement fixation
Intracellular parasites
Exogenous toxic factors

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5
Q

Morphologic intravasular hemolysis

A

EPO
Retic
Hemosiderosis
Pigment gallstones

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6
Q

Intrinsic defect

Autosomal dominant

A

Hereditary spherocytosis

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7
Q

What can triggered HS

A

Acute parvo virus infection

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8
Q

X linked recessive trait

Male affected

A

G6PD

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9
Q

Benefit of G6PD

A

Protection against plasmodium

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10
Q

What can trigger G6PD

A

Infections hep,pneumo and typhoid
Drugs
Fava beans

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11
Q

What can be seen with G6PD

A

Heinz bodies
Schistocytes
Spherocytes

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12
Q

Due to point mutation in the 6th codon glutamate to valine

A

Sickle cell diseasea

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13
Q

Major pathologic manifestation of SC

A

Chronic hemolysis
Mircovascular occlusion
Tissue damage

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14
Q

Most serious clinical feature of SC

A

Microvascular occlusion

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15
Q

Morphological feature of SC

A

Howell jolly bodies
New bone formation
Autosplenectomy

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16
Q

Treatment for Sequestration crisis and acute syndrome

A

Exchange transfusion

17
Q

Acquired PIGA

A

PNh

18
Q

Diagnosis and treatment of PNH

A

Flow cytometry

BM transplant

19
Q

Causes by autoimmune gastritis and failure of IF production

A

Pernicious anemia

20
Q

Clinical features of folate deficiency

A

cheilosis
Glossitis
Dermatitis

21
Q

Common cause of Pure red cell aplasia

A

Parvo B19

22
Q

Clinical features of IDA

A

CNS - Pica

Plummer vinson syndrome

23
Q

Notable in Anemia of chronic disease

A

Increase hepcidin

24
Q

Increase EPO in Polycythemia

A

Secondaey

25
Q

Weak vessel walls

A

Scurvy and EDS

26
Q

Due to hypersensitivity

A

Henoch schonlein purpura

27
Q

Common under mucous membrane or epistaxis

Dilated tortuous blood vessels

A

Hereditary hemorrhagic telegiectasia

Weber osler rendu syndrome

28
Q

Vessel wall abnormality that is common among amyloid light chain

A

Perivascular amyloidosis

29
Q

When is spontaneous bleeding seen

A

20,000

30
Q

IgG that are directed towards 2B-3A or 1b-1x

A

Thrombocytopenic purpura

31
Q

Normal levels of ADAMTS13

A

HUS

32
Q

Acquired platelet defects

A

Aspirin

Uremia

33
Q

Assessment of vWF

A

Ristocetin test

34
Q

VWF due to missense mutation

A

Type 1

35
Q

Type of Vwf due to deletion or frameshift of both alleles

A

Type 3

36
Q

Consumption of platelets, fibrin and coagulation

A

DIC

37
Q

DIC to meningococcemia

A

Waterhouse friderichsen syndrome

38
Q

Lab results of DIC

A

Increase PT PTT FDP

Patho A (15 decks)

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