RBC

Question 1

How do you asses acute blood loss

Answer 1

Reticulocytosis

Question 2

When would you diagnose chronic anemia

Answer 2

Iron reserves are depleted

Question 3

Clinical features of extravascular hemolysis

Answer 3

Anemia
Splenomegaly
Jaundice

Question 4

Causes of intravascular hemolysis

Answer 4

Mechanical injury
Complement fixation
Intracellular parasites
Exogenous toxic factors

Question 5

Morphologic intravasular hemolysis

Answer 5

EPO
Retic
Hemosiderosis
Pigment gallstones

Question 6

Intrinsic defect

Autosomal dominant

Answer 6

Hereditary spherocytosis

Question 7

What can triggered HS

Answer 7

Acute parvo virus infection

Question 8

X linked recessive trait

Male affected

Answer 8

G6PD

Question 9

Benefit of G6PD

Answer 9

Protection against plasmodium

Question 10

What can trigger G6PD

Answer 10

Infections hep,pneumo and typhoid
Drugs
Fava beans

Question 11

What can be seen with G6PD

Answer 11

Heinz bodies
Schistocytes
Spherocytes

Question 12

Due to point mutation in the 6th codon glutamate to valine

Answer 12

Sickle cell diseasea

Question 13

Major pathologic manifestation of SC

Answer 13

Chronic hemolysis
Mircovascular occlusion
Tissue damage

Question 14

Most serious clinical feature of SC

Answer 14

Microvascular occlusion

Question 15

Morphological feature of SC

Answer 15

Howell jolly bodies
New bone formation
Autosplenectomy

Question 16

Treatment for Sequestration crisis and acute syndrome

Answer 16

Exchange transfusion

Question 17

Acquired PIGA

Answer 17

PNh

Question 18

Diagnosis and treatment of PNH

Answer 18

Flow cytometry

BM transplant

Question 19

Causes by autoimmune gastritis and failure of IF production

Answer 19

Pernicious anemia

Question 20

Clinical features of folate deficiency

Answer 20

cheilosis
Glossitis
Dermatitis

Question 21

Common cause of Pure red cell aplasia

Answer 21

Parvo B19

Question 22

Clinical features of IDA

Answer 22

CNS - Pica

Plummer vinson syndrome

Question 23

Notable in Anemia of chronic disease

Answer 23

Increase hepcidin

Question 24

Increase EPO in Polycythemia

Answer 24

Secondaey

Question 25

Weak vessel walls

Answer 25

Scurvy and EDS

Question 26

Due to hypersensitivity

Answer 26

Henoch schonlein purpura

Question 27

Common under mucous membrane or epistaxis

Dilated tortuous blood vessels

Answer 27

Hereditary hemorrhagic telegiectasia

Weber osler rendu syndrome

Question 28

Vessel wall abnormality that is common among amyloid light chain

Answer 28

Perivascular amyloidosis

Question 29

When is spontaneous bleeding seen

Answer 29

20,000

Question 30

IgG that are directed towards 2B-3A or 1b-1x

Answer 30

Thrombocytopenic purpura

Question 31

Normal levels of ADAMTS13

Answer 31

HUS

Question 32

Acquired platelet defects

Answer 32

Aspirin

Uremia

Question 33

Assessment of vWF

Answer 33

Ristocetin test

Question 34

VWF due to missense mutation

Answer 34

Type 1

Question 35

Type of Vwf due to deletion or frameshift of both alleles

Answer 35

Type 3

Question 36

Consumption of platelets, fibrin and coagulation

Answer 36

DIC

Question 37

DIC to meningococcemia

Answer 37

Waterhouse friderichsen syndrome

Question 38

Lab results of DIC

Answer 38

Increase PT PTT FDP