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Patho A > Immune 1 > Flashcards

Immune 1 Flashcards

1
Q

What are the components of the innate immunity

A 
Epithelial barrier 
Phagocytic cell
Dendritic cell
NK cells
Mast cells
Innate lymphoid cell
Soluble protein
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2
Q

Toll like receptors are present where

A

Plasma membrane

Endosomal membrane

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3
Q

What type of receptor is nod like receptor

A

Cytosolic receptor

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4
Q

Inflammasome will activate

A

Caspase1

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5
Q

NLR inflammasome pathway can recognize and detect what

A

Uric acid from gout

Lipid and cholesterol from Atherosclerosis and DM2

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6
Q

This receptor can detect fungal glycan

A

C type Lectin receptor

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7
Q

They are mature lymphocytes that have not encountered the antigen

A

Naive lymphocyte

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8
Q

Naive lymphocyte that are activated by recognition of antigen

A

Effector cells

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9
Q

This enzymes are responsible for the recombination of antigen receptor gene

A

Rag1

Rag2

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10
Q

This involvesin transduction of signals into the T cells that are triggered by the binding of the antigen

A

CD 3 and Gamma protein

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11
Q

What are the components of the TCR complex

A

CD3 + TCR - gamma protein

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12
Q

This are considered to protect against micro that invade epithelial

A

Gamma polyprotein

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13
Q

These antibodies are present in the naive B cells that serve as its antigen binding component

A

IgM and IgD

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14
Q

This is used by the EBV to enter and infect B cells

A

CR2 or CD 21

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15
Q

Site of MHC 1 binding

A

Endoplastic Reticulum

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16
Q

Hypersensitivity type 1 are caused by

A

Th 2

IgE

Mast cells

17
Q

This is a cytotoxic reaction due to antibody and antigen complex

A

Type 2 hypersenticity

18
Q

3 mechanisms of type 2 hypersensitivity

A

Opsonization and phagocytosis

Complement and FC receptor mediated inflammation

Antibody mediated cellular dysfunction

19
Q

Opsonization and phagocytosis happens during

A

Transfusion reaction

Erythroblastosis fetalis

Autoimmune anemia

Drug reactions hapten

20
Q

Complement and FC receptors mediated inflammation happens during

A

Glomerulonephritis

Vascular rejection

Good pasture syndrome

21
Q

Antibody mediated cellular dysfunction happens during

A

Myasthenia Gravis

Graves’ disease

22
Q

FOXP3 mutation causes a systemic immune disease

A

Immune dysregulation
Polyendocrinopathy
Enteropathy
X-linked

23
Q

Polymorphism in CD25 will cause

A

Multiple sclerosis

24
Q

Mutation in the FAS gene will cause

A

Autoimmune lymphoproliferative syndrome

ALPS

25
Q

What are considered immune privileged sites

A

Brain
Eyes
Testis

Patho A (15 decks)

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