Immune 1 Flashcards
What are the components of the innate immunity
Epithelial barrier Phagocytic cell Dendritic cell NK cells Mast cells Innate lymphoid cell Soluble protein
Toll like receptors are present where
Plasma membrane
Endosomal membrane
What type of receptor is nod like receptor
Cytosolic receptor
Inflammasome will activate
Caspase1
NLR inflammasome pathway can recognize and detect what
Uric acid from gout
Lipid and cholesterol from Atherosclerosis and DM2
This receptor can detect fungal glycan
C type Lectin receptor
They are mature lymphocytes that have not encountered the antigen
Naive lymphocyte
Naive lymphocyte that are activated by recognition of antigen
Effector cells
This enzymes are responsible for the recombination of antigen receptor gene
Rag1
Rag2
This involvesin transduction of signals into the T cells that are triggered by the binding of the antigen
CD 3 and Gamma protein
What are the components of the TCR complex
CD3 + TCR - gamma protein
This are considered to protect against micro that invade epithelial
Gamma polyprotein
These antibodies are present in the naive B cells that serve as its antigen binding component
IgM and IgD
This is used by the EBV to enter and infect B cells
CR2 or CD 21
Site of MHC 1 binding
Endoplastic Reticulum
Hypersensitivity type 1 are caused by
Th 2
IgE
Mast cells
This is a cytotoxic reaction due to antibody and antigen complex
Type 2 hypersenticity
3 mechanisms of type 2 hypersensitivity
Opsonization and phagocytosis
Complement and FC receptor mediated inflammation
Antibody mediated cellular dysfunction
Opsonization and phagocytosis happens during
Transfusion reaction
Erythroblastosis fetalis
Autoimmune anemia
Drug reactions hapten
Complement and FC receptors mediated inflammation happens during
Glomerulonephritis
Vascular rejection
Good pasture syndrome
Antibody mediated cellular dysfunction happens during
Myasthenia Gravis
Graves’ disease
FOXP3 mutation causes a systemic immune disease
Immune dysregulation
Polyendocrinopathy
Enteropathy
X-linked
Polymorphism in CD25 will cause
Multiple sclerosis
Mutation in the FAS gene will cause
Autoimmune lymphoproliferative syndrome
ALPS
What are considered immune privileged sites
Brain
Eyes
Testis
